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{
"caption": "Histopathological specimen of resected liver tumour, 200×. Necrotic masses within the tumour.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839091-1-1477-7819-5-36-4.jpg"
} | 001100 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histopathological specimen of resected liver tumour, 200×. Necrotic masses embolism inside a portal vein branch.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839091-2-1477-7819-5-36-3.jpg"
} | 001101 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Computed tomography, A – multiple focal changes in liver are visible, B – multiple metastases to lungs are visible.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839091-3-1477-7819-5-36-1.jpg"
} | 001102 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "An example of subtracting two images that were captured by time-lapse optical microscopy. (A) Initial image. (B) The same area with (A) captured after 30 s. (C) subtracted image of (A) and (B). Three days incubation on the CMS SAM without rinsing. Horizontal size of the images is 5.3 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839107-0-1477-3155-5-2-7.jpg"
} | 001103 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Optical microscopic images of diatom cells on SAM surfaces incubated for 3 days. (A) FPS. (B) OTC. (C) CMS. (D) APS. The sample was rinsed after one day of incubation. Horizontal size of the images is 2.7 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839107-4-1477-3155-5-2-6.jpg"
} | 001104 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "AFM images of chemically modified glass surfaces. (A) FPS, (B) OTC, (C) APS, and (D) CMS. Scan size was 1 μm. Values on each image showed static water contact angle (θw).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839107-7-1477-3155-5-2-10.jpg"
} | 001105 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Optical microscopic images of diatom cells cultured on four types of SAM surfaces. (A), (E): FPS. (B), (F): OTC. (C), (G): CMS. (D), (H): APS. (A) to (D): unrinsed. (E) to (H): rinsed after one day of incubation. The incubation period was 40 days. Horizontal size of the images is 5.3 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839107-8-1477-3155-5-2-3.jpg"
} | 001106 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Optical microscopic images of diatom cells cultured on CMS surfaces. (A) unrinsed. (B) rinsed. The incubation period was 40 days. Horizontal size of the images is 2.7 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839107-9-1477-3155-5-2-4.jpg"
} | 001107 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Subcellular localisation of the Tax, Rex, R3 and G4 proteins. Hela cells were transfected with expression vectors for Tax, Rex, R3 and G4, cultivated during 24 hours, indirectly marked with FITC-conjugated antibodies and visualized under a fluorescent microscope.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839114-4-1742-4690-4-18-3.jpg"
} | 001108 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Canulation of mesenteric lymphatic vessels. The lymphatic vessels and the lymph nodes were colored by injection of Evans blue and dwelling catheters were inserted into the efferent lymphatics.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_108-PMC1839114-6-1742-4690-4-18-5.jpg"
} | 001109 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "IHC staining for CD56 and CD8 in BCC from (a) P40 (imiquimod treated) and (b) P8 (vehicle-control). Lesions were graded blindly by two pathologists (AA and AF) and graded before and at EOT for peri-tumoral and intra-tumoral immune cells infiltrate. Cancer cells were evaluated separately for each marker. When BCC was absent at EOT as in P40 the immune infiltrate was compared to the peri-tumoral pre-treatment infiltrate. NE, not evaluable because no tumor cells were left at EOT.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839129-2-gb-2007-8-1-r8-4.jpg"
} | 001110 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Eye Defects and Body-Axis Duplications Observed in AMN PopulationDorsal views shown are: (A) Unilateral anophthalmia; (B) Unilateral microphthalmia; and (C) Unilateral nanophthalmia (UN), illustrating retina (re), lens (le), cornea (co). (D) Ventral view of cyclopic embryo is shown. (E) Bilateral anophthalmia is shown (top, lateral view; bottom, dorsal view). (F) Anterior body-axis duplication (ABD), two complete heads formed; incomplete ABD were also observed (not shown). (G) Posterior body duplication (PBD), two notochords showing adjacent somite boundaries (arrows), culminating in two tails.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839141-10-pgenp0030043pg004.jpg"
} | 001111 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Assessing Range of Expressivity and Quantifying Phenotype Modulation in sri and dre Strains(A–H) Phenotype of the sri and dre eye mutants at 5 dpf. (A–D) Lateral view of live embryos; (E–H) histological sections. (A) WT; lens (white-dotted lines) and retina (red-dotted lines) measurements were used to asses phenotypic severity; (E) WT section showing retina (re), lens (le), cornea (co); (B) and (F) sri mild and (C) and (G) sri severe; (D) dre with coloboma (cb); (H) dre showing flattened anterior segment.(I and J) Ranked plots showing distribution of quantitative eye parameters in treated (white circles) and sibling control (black circles) homozygous embryos: (I) Ratio of retina to lens area; (J) Lens shape or eccentricity.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839141-9-pgenp0030043pg003.jpg"
} | 001112 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "L. monocytogenes PGN Is Degraded in the Phago-Lysosome and Induces NOD2-Dependent Responses(A) Immunofluorescence microscopy of activated and non-activated BMD macrophages infected with FL-Van–labeled LLO-minus mutant. FL-Van labeling localized to bacterial poles (arrowheads and magnified picture).(B) Response of activated macrophages to L. monocytogenes CW preparation and CW degradation fragments (L.m.CW fragments) delivered with lipofectamine. Level of TNFα, IL-6, and IFN-β induction determined by Q-RT-PCR.(C) Induction of IFN-β response by L. monocytogenes CW fragments in Myd88/Trif double-knockout activated macrophages. Data correspond to the mean ± s.e.m. (triplicate determinations).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839167-3-ppatp0030051pg005.jpg"
} | 001113 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "A soft, bluish foreign body seen to fill the mastoid antrum up to the attic area.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839759-0-1752-1947-1-3-1.jpg"
} | 001114 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Sagittal T2-weighted magnetic resonance image of spine at admission. There is longitudinal hyperintense signal involving the central cord from C1 downwards.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839762-0-1752-1947-1-4-2.jpg"
} | 001115 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Axial FLAIR sequence magnetic resonance image of brain at admission. There are hyperintense multifocal lesions in the deep grey nuclei, subcortical white matter and cortex.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839762-2-1752-1947-1-4-1.jpg"
} | 001116 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "T2* weighted spiral imaging of the right common carotid artery in-vivo, pre (A) and 36 hours post USPIO infusion (B) showing signal loss in areas of USPIO uptake (yellow arrows). (The 2D T2* weighted spiral acquisition used a spectral-spatial excitation pulse, with a TE of 5.6 ms. The multi-shot spiral sequence involved the acquisition of 22 spiral interleafs each of 4096 data points resulting in an effective in-plane pixel size of 0.42 × 0.42 mm, two signal averages were performed and a quadruple inversion preparation was utilised to null the signal from blood pre – and post USPIO. Slices were acquired sequentially with a 3 mm thickness and no inter-slice gap.). Pre (C) and 36 hours post USPIO infusion (F) T2* weighted spiral imaging in-vivo revealing signal drop in the wall of the aneurysm post-USPIO (yellow arrows) likely corresponding to regions with a high inflammatory burden. Corresponding ex-vivo imaging in a dedicated micro-coil with T2 map (D) showing regions with very short T2 species (yellow arrow) corresponding with area of USPIO uptake. Ex-vivo inversion recovery on-resonance water suppression (IRON) imaging [9] (E) with off-resonant spins showing positive contrast due to dephasing of spins adjacent to USPIO uptake. H&E section (x40) co-registered with ex-vivo imaging (using distance from the bifurcation). Area of intraplaque haemorrhage within a small necrotic lipid core can be seen (red arrow), adjacent to the USPIO uptake seen in the ex-vivo imaging. Structural MR Imaging in the same patient reveals anatomy of the co-existing abdominal aortic aneurysm (H&J).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839766-0-1750-1164-1-4-1.jpg"
} | 001117 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Minor bleeding control using HPA tampon, during thyroidectomy. The porous design of the tampon allows performing an effective aspiration of blood and unwanted fluid, by positioning the tampon directly on the bleeding surface (for example, close to RNL) and using the suction device right through the tampon itself.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839768-0-1750-1164-1-3-1.jpg"
} | 001118 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Wild type and ob/ob mice liver cells. Liver tissue images of wild type (WT) and ob/ob mice.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1839890-7-1752-0509-1-12-4.jpg"
} | 001119 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Histologic (H&E) findings of three components of AMLEC. (A) Epithelial cysts lined by cuboidal to hobnail cells. Original magnification X400. (B) Compact subepithelial \"cambium-like\" layer of cellular, mullerian-like AML stroma with prominent admixed chronic inflammation. Original magnification X200. (C) Muscle-predominant AML with associated dysmorphic blood vessels. Original magnification X200. (D) Non-cystic native tubules entrapped in muscle-predominant AML. Original magnification X200.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845137-0-1746-1596-2-11-1.jpg"
} | 001120 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunohistochemical (IHC) findings of AMLEC. (A) Compact subepithelial stroma showed diffuse strong CD10 staining. Original magnification X200. (B) Diffuse strong vimentin staining in all 3 components equally. Original magnification X200. (C) Epithelium lining the cystic spaces showed strong intense pancytokeratin staining. Original magnification X200. (D) Ki67 staining showed low proliferative index of less than 1% of neoplastic cells. Original magnification X200.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845137-1-1746-1596-2-11-3.jpg"
} | 001121 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunohistochemical (IHC) findings of AMLEC. (A) Compact subepithelial stroma showed most intense HMB45 staining. Original magnification X200. (B) Muscle-predominant AML showed most intense smooth muscle actin staining. Original magnification X200. (C) Compact subepithelial stroma showed diffuse strong ER staining. Original magnification X200. (D) Compact subepithelial stroma showed diffuse strong PR staining. Original magnification X200.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845137-2-1746-1596-2-11-2.jpg"
} | 001122 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Chest HRCT performed 10 months after WLL. Areas of ground glass attenuation are no longer visible; only minimal interlobular septa thickening is still evident.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845139-0-1750-1172-2-14-2.jpg"
} | 001123 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Chest HRCT performed 1 day before WLL. Areas of ground glass attenuation with concomitant interlobular septa thickening are evident, alternated with areas of normal lung (crazy paving pattern).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845139-1-1750-1172-2-14-1.jpg"
} | 001124 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Dental occlusion. A, B. Preoperative: Patient reported for preoperative orthodontic treatment. Class II occlusion with deep bite, dental crowding and convergent inclination of posterior upper teeth are observed. Tooth 47 is lacking. C, D. Postoperative: dental occlusion surgical and orthodontic treatments completed with correction of deep bite. Dental alignment and levelling improve stability of surgical results, characterized by acquisition of molar and canine occlusion keys associated with good intercuspidation and interdigitation of the remaining dental structures.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845144-1-1746-160X-3-15-6.jpg"
} | 001125 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Radiographic comparison. A. Lateral extra-oral radiograph for preoperative cephalometric investigation of a retrognathic patient. Skeletal image of the retropositioned mandible can be seen in type II occlusal relationship. Soft structures show characteristic deep mentolabial sulcus and small facial height. B. Postoperative lateral extra-oral radiograph. Alveolar osteotomy can be seen from 32 to 42, associated to advancement and clockwise rotation of the mandible making up a maxilla-combined surgery. The surgery begins at the mandible. Rigid fixation miniplates measuring 2 mm are used in an extension of six holes for an advancement of 13 mm. On the maxilla, 1.5 mm rigid fixation may be observed. Soft tissue profile in accordance with skeletal results. In the naso-oro-hypopharyngeal regions, pre- and postoperative images show transversal increase of the area. This result is supported by respiratory improvement, as clinically reported by the patient.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845144-2-1746-160X-3-15-3.jpg"
} | 001126 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Transoperative characteristics. A. Osteotomy extending from medial aspect of the ascending ramus above the lingula, over the oblique external line to the mesial face of the permanent first molar. This cut is then extended vertically to the lower border of the mandible. The winding tracing is noteworthy. B. Separation of fragments after bone split. Larger extension of lateral segment and, in consequence, larger surface for bone contact. Exposition of the cruent area, including in its extension the neurovascular bundle; mental nerve. C. Complete liberation of osteotomized segments, allowing ample sliding between them. The lateral external segment of mandibular ramus and body is shown. Its extension and magnitude are noteworthy. Cruent area clearly visible in the depth of the bone surgical wound. Mandibular body. D. Application of miniplate and screw end surgical procedure in one of the sides. The sequence is repeated in the opposite side.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845144-5-1746-160X-3-15-2.jpg"
} | 001127 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Histology of figure 1. This is a moderately differentiated SCCA (H&E).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845148-0-1477-7819-5-34-2.jpg"
} | 001128 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Fibrotic stricture which developed after the second cryospray ablation treatment.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845148-1-1477-7819-5-34-5.jpg"
} | 001129 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Endoscopic appearance of the SCCA (figure 1) one month after cryospray ablation.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845148-2-1477-7819-5-34-4.jpg"
} | 001130 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Cryospray ablation (CSA) of the SCCA in figure 1. On the left is the cryo decompression tube. In the right fore corner is the cryo catheter.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845148-3-1477-7819-5-34-3.jpg"
} | 001131 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Squamous cell carcinoma (SCCA) in the proximal esophagus at 24 cm from the incisors. This lesion occurred above the prior radiation therapy treatment field.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845148-4-1477-7819-5-34-1.jpg"
} | 001132 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Original TRUS Image2, Manually Segmented, Second Eigenvector.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845149-21-1475-925X-6-10-5.jpg"
} | 001133 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Immunostaining of normal background breast tissue (left Panel) and breast cancer tissue (Right Panel) for Ang-1, Ang-2 and Tie-2 (original magnification, 40×, 100×; 200× and 400×). A higher intensity of staining was noted in epithelial cells of breast cancer compared with non-cancerous mammary tissue. Strong staining of Ang-1, Ang-2 and Tie-2 is shown in normal breast duct compared to breast cancer duct.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1845167-1-1477-7800-4-6-5.jpg"
} | 001134 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Emigration of CD207+ cells into the dermis. Transverse section of pinna on day 2 (a) shown under bright field demonstrating a parasite in the epidermis. Confocal image of the same section (b) showing CD207+ cells (green) in relation to the parasite (red). Focal grouping (c and d) of emigrating CD207+ cells in the dermis on day 4. Cytospins of dermal exudates cell (DEC) population under (e) phase contrast and (f) stained for CD207. The majority of DECs (g) are MHCII+ (red) and only a minority are CD207+ (green). Scale bars = 25μm. Mean number ± SEM of CD207+ cells per mm2 dermis (h) of naïve mice or on day 4. Significance values are for day 4 cf. day 0 ∗P < 0.05.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847335-1-gr4.jpg"
} | 001135 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Localisation of CD207+ cells on epidermal sheets (a–c and f) and transverse sections of naïve mouse pinna (d and e). Cells were labelled with rat IgG control (a), rat anti-CD207 probed with anti rat Alexafluor 488 (green; b–f) and biotinylated anti-MHCII probed with streptavidin Texas-Red (f). Scale bars indicate 10 μm. Key: e, epidermis; d, dermis; c, cartilage.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847335-4-gr1.jpg"
} | 001136 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Rheb and TOR regulate ribosome biogenesis. (A, B) Nucleoli visualized by anti-fibrillarin staining (green) [84], in S2 cells treated with (A) DMSO or (B) rapamycin for 16h. DNA was visualized using Hoechst 33258 (blue). (C) Northern blots of RNA from S2 cells treated for 72h with the indicated dsRNA. A probe for an internal transcribed spacer (ITS) region of the rDNA was used to detect pre-rRNA. Total rRNA was detected with ethidium bromide. A probe for dMyc transcript was used as a loading control. (D) Quantification, using ImageJ software, of pre-rRNA and total rRNA, relative to dMyc mRNA, from the samples shown in (C).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847425-2-1741-7007-5-10-4.jpg"
} | 001137 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "a Posterior anterior chest x-ray of 57-yr-old male with T3N2M1 non-small cell lung cancer demonstrates a left hilar mass with loss of volume and/or post obstructive pneumonia in the left lower lobe. b Axial computed tomography chest angiogram demonstrates total occlusion of the left mainstem bronchus by a tumor invading from the left hilum.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847429-0-1749-8090-2-16-1.jpg"
} | 001138 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "a Videobronchoscopy image demonstrates distal left mainstem bronchus occlusion. b Videobronchoscopy image demonstrates debridement of malignant distal mainstem occlusion with the rotating tip tracheal microdebrider after argon plasma coagulation. c Videobronchoscopy image demonstrates a nitinol self-expandable metal stent in the previously occluded left mainstem bronchus.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847429-1-1749-8090-2-16-2.jpg"
} | 001139 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Posterior anterior chest x-ray demonstrates satisfactory stent placement with re-expansion of the left lower lobe.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847429-2-1749-8090-2-16-4.jpg"
} | 001140 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Localization of cPRP1, cPRP6, bPRP1 and bPRP6 in the caprine and bovine placentome on Day 50 and 60 of gestation. (A, B, C) cPRP1, (D, E, F) cPRP6, (G, H, I) bPRP1, and (J, K, L) bPRP6 mRNA were detected by in situ hybridization. (A, B, D, E, G, H, J, K) DIG-labeled anti-sense cRNA probes were used. (C, F, I, L) DIG-labeled sense cRNA probes were used. Seven micrometer sections of caprine and bovine placentome were hybridized with each probe. Scale bar = 100 μm on (A, C, D, F, G, I, J, L) and 5 μm on (B, E, H, K).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847437-4-1471-213X-7-16-5.jpg"
} | 001141 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Inhibition of the MEK1/2-ERK1/2 pathway stimulates tibia growth, while p38 MAPK is required for CNP-induced bone growth. Mouse E15.5 tibiae were harvested and cultured for six days in the presence of control or CNP (1 μM) and vehicle (DMSO) or MEK1/2-ERK1/2 pathway inhibitors PD98059 (10 μM) and U0126 (10 μM) (A). Though both PD98059 and U0126 stimulated basal bone growth, inhibition of the MEK1/2-ERK1/2 pathway did not further enhance CNP-induced bone growth (*: p < 0.05 when comparing control/inhibitors to control/vehicle; #: p < 0.05 when comparing CNP/vehicle to control/vehicle; p > 0.05 when comparing CNP/vehicle to CNP/inhibitors). Tibiae were incubated with control or CNP and pharmacological inhibitors of the p38 MAPK pathway (SB202190 or PD169316, 10 μM each) or an inactive analog (SB202474, 10 μM) (B). p38 inhibition did not effect basal bone growth significantly, but did suppress CNP-induced bone growth (*: p < 0.05 when comparing CNP/inhibitors to CNP/SB202474; #: p < 0.05 when comparing CNP/SB202474 to control/SB202474). Bone growth was measured over an extended time course of eight days, showing that CNP continued to significantly influence growth on day 8, while SB202190 reversed these effects (C). Bones from each treatment were weighed under different conditions, and it was found that p38 inhibition reversed the effects of CNP on weight (D). Protein extracts from primary chondrocytes cultured with control, CNP (10-6M), or 8-(4-cpt) cGMP (0.1 mM) for 10 minutes were examined for phosphorylation of the p38 activators MKK3/6 by western blot analysis (E). Both treatments increased phosphorylation of MKK3/6, supporting the stimulation of p38 MAP kinase activity by CNP signaling. Immunohistochemistry with an antibody against phosphorylated p38 demonstrates markedly higher signal in CNP-treated tibiae when compared to control bones (F).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847438-4-1471-213X-7-18-3.jpg"
} | 001142 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "p38 MAPK activity is required for CNP-induced hypertrophy. E15.5 tibiae were isolated and incubated with or without CNP (1 μM) and DMSO or SB202190 (10 μM). Hematoxylin and Eosin staining of tibia sections after six days of culture show that p38 inhibition reversed CNP-induced expansion of the hypertrophic zone (A). Tibiae were stained with Alizarin Red and Alcian Blue, and representative images demonstrate increased bone growth by CNP and the reversal of these effects upon p38 inhibition (B). The area of the mineralized zone (red) was measured as absolute area (C, bottom) and as a percentage of total area (C, top), demonstrating that CNP-treated bones displayed significantly smaller mineralized area in relation to the whole bone area. This was reversed upon p38 inhibition. Representative images are shown, while all data represent means ± SD of four independent trials, each with six bones (p < 0.05).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847438-5-1471-213X-7-18-4.jpg"
} | 001143 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "CNP induces expansion of the hypertrophic zone. Hematoxylin and Eosin staining of tibia sections after six days of culture with or without CNP (1 μM) showed differences in growth plate architecture, primarily in the hypertrophic zone. CNP treatment results in a vastly expanded hypertrophic zone (A; hypertrophic zones indicated by brackets). Magnification of cells in the hypertrophic zone (boxes from A) shows that individual chondrocytes are larger in CNP-treated tibiae (B).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847438-7-1471-213X-7-18-2.jpg"
} | 001144 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Abdominal X-ray of patient 1 at first presentation. Note heavily dilated colon frame.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847445-0-1471-230X-7-14-1.jpg"
} | 001145 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Abdominal X-ray of patient 2 at the time of first presentation showing complete colon obstruction and dilatation (A). Colonoscopic view of the sigmoid tumor with complete obstruction (B). Colonoscopic view during APC ablation of the tumor (C); X-ray enema two days after APC ablation showing the channel through the stenosis (D).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847445-2-1471-230X-7-14-3.jpg"
} | 001146 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Colonoscopic picture of patient 1 at first presentation showing stenosis of the sigmoid which could not be passed by the colonoscope (A). Endoscopic snare debulking of the distal part of the tumor allowed to push the wire beyond the stenosis (B). After passing the tumor APC ablation of the proximal part of the tumor could be performed opening a channel (C). View of the stenosis after complete debulking. Note the channel with stool covering the luminal surface (D).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847445-3-1471-230X-7-14-2.jpg"
} | 001147 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Immunohistchemical study of liver cirrhosis:\n(a) MIB1 nuclear staining in hepatocytes; (b) granular cytoplasmic\nexpression of bFGF in hepatocytes; (c) thymidine phosphorylase expression in\nthe cytoplasm and nuclei of hepatocytes; (d) cytoplasmic expression of VEGF\nin hepatocytes. The adjacent fibrous bands do not express any of these\nproteins.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847476-0-MI2007-67187p001.jpg"
} | 001148 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Localization and relative quantification of AmUSP mRNA in mushroom bodies of the bee brain. A. The mushroom bodies are seen in transverse section through the brain of a 1 day old hybridized with probe for AmUSP. B. Mushroom bodies of a > 21 day old forager brain hybridized with the same probe as A. Asterisk indicates the region of the inner compact Kenyon cells. K cbs, Kenyon cell bodies; Oc, ocelli; Pt, protocerebrum. Scale bars = 100 µm. C. qRT-PCR analysis of AmUSP expression in individual mushroom bodies of 7 day pupae, 1 day workers, new precocious foragers (NPF), experienced precocious foragers (EPF), and foragers older than 21 days (2 genotypes; N = 8 brains per group). Data are means ± SE (converted as relative units to the lowest group mean). P and F-values for a one way anova are indicated. Bars with the same letter indicate means are not significantly different (t-test for LSD P > 0.05).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847479-1-imb0015-0583-f4.jpg"
} | 001149 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Iocalization of mRNA encoding AmPNR-like in the pupal head. A. Transverse section of a developing compound eye hybridized with probe for AmPNR-like (arrows); the most intense signal is restricted to a row of large cells along the proximal portion of the retina. The developing optic lobe is visible to the left. Scale bar = 100 m. B. Sagittal section hybridized with the same probe as in A. Scale bar = 50 m.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847479-2-imb0015-0583-f3.jpg"
} | 001150 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Localization and relative quantification of AmSVP mRNA in mushroom bodies of the bee brain. A. Mushroom bodies corresponding to a transverse section of a 1 day old worker brain section hybridized with probe for AmSVP. B. Mushroom bodies of a > 21 day old forager brain hybridized with the same probe as A. K cbs, Kenyon cell bodies; Oc, ocelli; Pt, protocerebrum. Scale bars = 100 µm. C. qRT-PCR analysis of AmSVP expression in individual mushroom bodies of 7 day pupae, 1 day workers, new precocious foragers (NPF), experienced precocious foragers (EPF), and foragers older than 21 days (2 genotypes; N = 8 brains per group). Data are means ± SE (converted as relative units to the lowest group mean). P and F-values for a one way anova are indicated. Bars with the same letter indicate means are not significantly different (t-test for LSD P > 0.05).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847479-4-imb0015-0583-f5.jpg"
} | 001151 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "The reproductive tracts of an immature (a) and mature (b) honey bee drone. Testes, seminal vesicles and mucus glands are labelled.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847503-0-imb0015-0541-f1.jpg"
} | 001152 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Typical FEG-SEM picture showing the octahedral morphology of pyrite grains formed at 200°C. Particles are 0.5 – 1.2 μm in size. Inset: Close-up of one particle showing the aggregation of smaller octahedra (50 – 100 nm).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847509-5-1467-4866-8-1-9.jpg"
} | 001153 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Typical HRTEM picture of greigite formed at 200°C in the presence of 10 mol-% of zerovalent sulfur as polysulfide and quenched with liquid nitrogen to -196°C. (A) The overview shows defects inside the crystal along crystallographic planes (arrows). (B) Three sets of lattice fringes are marked in the close-up: Set 1 has a distance of 0.56 nm, set 2 and 3 have a distance of 0.50 nm. Set 2 forms angles of 70° and 55° with sets 3 and 1, respectively. The distances and angular separations of the crystallographic planes are consistent with a greigite crystal viewed along the [01-1] crystal axis. Lattice fringe sets 2 and 3 correspond to the {111} plane and set 1 corresponds to the {200} plane. White arrows highlight a crystal defect causing a slight mismatch between adjacent lattices.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847509-6-1467-4866-8-1-8.jpg"
} | 001154 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Fluorescence microscopy and flow cytometric analysis of SYTO 45-stained chloroplasts. Brightfield (A) and fluorescence (B) microscopic images of chloroplasts isolated from 14-day-old seedlings after staining with 20 μM SYTO 45. The exposure time for (B) was 0.1 s. (C) Flow cytometric analysis of the same chloroplasts stained with the indicated concentrations of SYTO 45. Scale bar is 10 μm. Chloroplasts in all panels were not fixed.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847512-0-1746-4811-3-5-5.jpg"
} | 001155 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Comparison of SG and DAPI using fluorescence microscopy. Chloroplasts isolated from seedlings at 20 days after imbibition stained with DAPI (B) or SG (D). (A, C) Brightfield images of the chloroplasts shown in (B) and (D). The contrast has been enhanced (inset in (B)) to accentuate fluorescence from the chloroplasts in the lower left quadrant. Scale bar is 10 μm. The exposure time for both (B) and (D) was 0.5 s. DAPI-stained chloroplasts were fixed in glutaraldehyde and SG-stained chloroplasts were not fixed.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847512-1-1746-4811-3-5-2.jpg"
} | 001156 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Distribution of NC(4 h) in ischemic and sham-operated mice at days 1, 7 and 14.NC were infused icv in the lesioned side. Drawings represent typical results and are based on n = 5 brains for each experimental condition.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847533-3-ponep0000373pg005.jpg"
} | 001157 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Confocal analysis of immunoreactivity of NC(4 h) - green - and nestin, GFAP or NG-2 - red - at day 1.Colocalization (arrows) can be observed between NC(4 h) and nestin, NC(4 h) and GFAP, NC(4 h) and NG-2. Images are taken in striatum, in proximity of the ventricular wall where most cells can be found at this time point. Bar: 25 µm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847533-4-ponep0000373pg006.jpg"
} | 001158 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Morphology of microglia/macrophages (red).CD11b immunopositive cells at day 1 after ischemia and NC(4 h) infusion display a round, phagocytic morphology in the injected (A) but not in the contralateral side were no NC are present (B). Microglia/macrophages appear to surround NC as evidenced in C were NC are marked with Hoechst (blue). A further detail of the interaction between these cells is provided in D where one microglia/macrophage appears to cap a NC (marked with 5-CFDA, green). Bar (A–C): 20 µm; bar (D): 7 µm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847533-7-ponep0000373pg010.jpg"
} | 001159 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Embryonic polarity defects after weak RNAi of B0511.9. (A) wild-type 2 cell embryo after asymmetric first division; anterior AB cell is larger than the posterior P1 cell. (B) B0511.9(RNAi) embryo showing a symmetric first division. (C) PAR-3 at the anterior cortex of a wild-type one-celled embryo at anaphase. (D) PAR-3 on the entire cortex of a B0511.9(RNAi) embryo at anaphase. (E) PAR-2 at the posterior cortex of the wild-type one-celled embryo in (C). (F) PAR-2 in cytoplasmic structures in the B0511.9(RNAi) embryo shown in (D). The PAR-2 antibody shows weak cross-reaction with microtubules. PAR-2 and PAR-3 distributions were scored in wild-type and B0511.9(RNAi) embryos from prophase to the two cell stage. We distinguished weak versus strong classes of PAR staining defects in B0511.9(RNAi) embryos: (1) weak: an enlarged domain of cortical PAR-3 with a reduced domain of cortical PAR-2. (2) strong: complete cortical PAR-3 with PAR-2 in cytoplasmic puncta. In embryos where both meiotic divisions occurred, scored by the presence of two polar bodies, 50% were in the weak class and 17% in the strong class (n = 18). In embryos with a meiotic division defect, scored by the presence of only one polar body, 23% were in the weak class and 63% were in the strong class (n = 49). The PAR distribution defects in B0511.9(RNAi) embryos having two polar bodies suggests that its polarity function is separable from its meiotic function.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847674-0-1471-213X-7-19-2.jpg"
} | 001160 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Meiotic metaphase arrest induced by strong RNAi of B0511.9. Pairs of pictures show DIC and fluorescence images of embryos in the uterus of a mother carrying a GFP::H2B transgene marking nuclei. (A, B) wild-type embryos show progressively more nuclei as divisions proceed. (C, D) B0511.9(RNAi) embryos are all arrested at the one cell stage; staining of such embryos for beta-tubulin (red) and DNA (blue) shows arrest stage is at meiotic metaphase I (inset). (E, F) emb-27/Cdc16(RNAi) embryos arrested in metaphase of meiosis I [15], a phenotype identical to that of B0511.9(RNAi) in (C, D). Arrows in (D) and (F) point to sperm chromatin, indicating that the embryos have been fertilized.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847674-3-1471-213X-7-19-1.jpg"
} | 001161 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "P2 caries. A and B: Intra-oral photographs of caries in the rostral infundibulum of a maxillary P2. A) Black arrow indicates a carious lesion. B) An investigation probe inserted into a carious lesion.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847679-3-1751-0147-49-10-2.jpg"
} | 001162 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Case 1: Clinical picture showing the ulcero-proliferative growth in the region of thyroid.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847680-0-1477-7800-4-8-1.jpg"
} | 001163 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Case 1: The Photomicrograph with nests of pleomorphic cells with abundant eosinophillic cytoplasm and multifocal areas of keratin formation along with intercellular bridging(hematoxylin-eosin 400×).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847680-2-1477-7800-4-8-3.jpg"
} | 001164 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Case 1: Computed tomography showing the growth with pressure on the trachea.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847680-3-1477-7800-4-8-2.jpg"
} | 001165 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Case 3: Clinical picture showing the recurrent growth, the scar of old surgery is also visible.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847680-4-1477-7800-4-8-5.jpg"
} | 001166 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Sample images of the 10 localisation classes of endogenously expressed proteins. (a) Microtubule, (b) Golgi, (c) Plasma membrane, (d) Actin cytoskeleton, (e) Nucleus, (f) Endosome, (g) ER, (h) Mitochondria, (i) Peroxisome, (j) Lysosome. Scale bar 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847687-0-1471-2105-8-110-3.jpg"
} | 001167 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Sample images of the 11 localisation classes of transfected proteins. (a) Microtubule, (b) Golgi, (c) Plasma membrane, (d) Actin cytoskeleton, (e) Nucleus, (f) Endosome, (g) ER, (h) Mitochondria, (i) Peroxisome, (j) Lysosome, (k) Cytoplasm. Scale bar 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847687-1-1471-2105-8-110-4.jpg"
} | 001168 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Threshold statistics for cell images. Once a cellular image (a) is thresholded (a'), statistics are calculated from the threshold image. For each white pixel the number of pixels adjacent that are also white are counted. Examples of having zero to eight white neighbours are given in (0)-(8). The first threshold statistic is then the number of white pixels with zero white neighbours, the second is the number with one white neighbour, and so on up to eight. These nine statistics are then normalised by dividing each by the total number of white pixels in the threshold image.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847687-2-1471-2105-8-110-2.jpg"
} | 001169 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Distinguishing cell images by thresholding. Images of the endoplasmic reticulum (a) and the microtubule cytoskeleton (b) are thresholded (a' and b') such that pixels with intensity in the range μ-30 to μ+30 are shown in white, where μ is the average pixel intensity of each image. Though images (a) and (b) are texturally and visually similar, images (a') and (b') are more distinguished. Image (a') contains more solid white regions, while (b') shows more interior speckling and feathering of edges.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847687-3-1471-2105-8-110-1.jpg"
} | 001170 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "SmInAct Is Essential for Egg Development(A) Treatment of adult parasites with dsRNA corresponding to SmInAct led to a 40% reduction in SmInAct mRNA levels. dsRNA treatment is indicated on the x-axis, where control worms were treated with luciferase dsRNA. Data are presented as the mean fold change in SmInAct expression (+/− s.d.) from three separate experiments, as determined by real-time RT-PCR using paramyosin as a reference gene for expression.(B) Developmental progression of eggs laid in vitro. Eggs produced by paired males and females during the first 48 h ex vivo were cultured in vitro for 5 d, and an egg from the developing majority was photographed. Stages of development approximate progressive 20-h periods. Scale bar = 110 μm.(C) Immature eggs produced by adult parasites ex vivo and soaked in SmInAct dsRNA failed to develop into miracidia. Eggs soaked in an irrelevant control dsRNA (luciferase, 1 μg/ml) developed through stage 6 within 5 d (left) while eggs soaked in SmInAct dsRNA (1 μg/ml) for the same period halted development at stage 2 (right). Main scale bar = 210 μm. Inset scale bar = 110 μm.(D) Quantitative analysis of the SmInAct dsRNA–induced developmental phenotype. Control- or SmInAct dsRNA–treated eggs were examined microscopically and scored as either developed or undeveloped based on the presence or absence of a miracidium. Data are presented as mean percent developed (+/− s.d.) from four separate experiments.(E) SmInAct protein levels are decreased by approximately 10-fold following treatment with SmInAct dsRNA. Protein extacts from 350 control or SmInAct dsRNA–treated eggs were separated via SDS-PAGE in 10-fold serial dilutions, blotted, and probed with anti-SmInAct antiserum. A silver-stained sister SDS-PAGE gel is shown to confirm protein loading.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847691-3-ppatp0030052pg003.jpg"
} | 001171 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Localization of N-terminal GFP Constructs of Rab28, FLJ32421/BROFTI, Prickle2 (507–844), and RhoA63L in HeLa CellsHeLa cells were analysed by fluorescence microscopy after transfection with the following constructs: inserts 1, 3, and 4—GFP-Rab28; insert 2—GFP-Rab28 C218A; inserts 5, 7, and 8—GFP-FLJ32421; insert 6—GFP-FLJ32421 C408A; inserts 9, 11, and 12—Prickle2; insert 10—GFP-Prickle2 C841A; inserts 13, 15, and 16—GFP-RhoA63L (as positive control for a geranylgeranylated target); insert 14—GFP-RhoA63L C190S. The GFP-RhoA plasmids were kindly provided by Channing J. Der (University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States). Nuclei were co-stained with DAPI (blue color).(A) GFP-Rab28, GFP-FLJ32421, and GFP-Prickle2 are membrane-localized with (4, 8, 12) or without (1, 5, 9) GGTI-298 treatment. Mutation of the Cys in the CaaX box (2, 6, 10) or treatment with FTI-277 (3, 7, 11) cause mislocalization and accumulation of the fusion proteins in the nucleus.(B) GFP-RhoA is membrane-localized with (15) or without (13) FTI-277 treatment. Mutation of the Cys in the CaaX box (14) or treatment with GGTI-298 (16) cause mislocalization and accumulation of RhoA in the nucleus.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847700-4-pcbip0030066pg010.jpg"
} | 001172 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Kakusei expression in the brains of bees that exhibited phototaxis. In situ hybridization was performed using thin sections (10 µm) of the brains of nurse bees that did not move to the light side (N = 4, A–D) and foragers that had phototactic behavior (N = 5, E–H). (C and G) Magnified views of boxed regions in panels (B) and (F), respectively. Bars indicate 100 µm. Arrows indicate kakusei-positive cells. Kakusei expression was detected both in the mushroom bodies (A and E) and optic lobes (B, C, F and G) of nurse bees (A–C) and foragers (E–G), and not in the antennal lobes (D and H).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847703-3-ponep0000371pg003.jpg"
} | 001173 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Re-orienting bees and foragers showed different kakusei expression patterns. (A–D) Representative in situ hybridization pictures of kakusei expression in re-orienting bees and foragers. Arrows indicate the kakusei-positive neurons. Note that kakusei expression pattern is different between the re-orienting bees and foragers. (E) Quantification of kakusei expression in the brains of re-orienting bees and foragers. (F) Ratio of kakusei density in the sKCs to lKCs. (G) Quantitative data of kakusei expression in re-orienting bees and dancers caught from transparent observation hives. Note the different kakusei expression pattern between re-orienting bees and dancers. (H) Ratio of kakusei density in the sKCs to lKCs. Asterisk indicates significant difference between foragers/dancers and the other groups (*, P<0.01; Tukey-Kramer's test after ANOVA).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847703-4-ponep0000371pg006.jpg"
} | 001174 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Temporal regulation of embryonic axis formation from rostral to caudal level.Animal views of S. canicula embryos after in situ hybridization using Otx1 (a–c), Otx2 (d–f), Gsc (g–i), HoxB1 (j–l), Cdx2 (m,n) and Mox1 (o, p) probes. For each probe, stages are indicated in the upper line. The views are focussed on the territories enclosed in dotted boxes in b, c, e, f, h, i, j, k, l, m, n, o, p. d', f', g', i', l', m', p': sections of hybridized embryos shown in d, f, g, i, l, m, p after eosin counterstaining. The planes of sections are indicated by thin lines on the whole-mount view of each embryo. Scale bar: 500 µm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847705-0-ponep0000374pg003.jpg"
} | 001175 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Molecular characterization of the dogfish embryo at pre-gastrula stages.A) Animal views of S. canicula embryos after in situ hybridization using Otx1 (a,h), Otx2 (b,i), Otx5 (c,j), FoxA2 (d,k), Lim1 (e,l,m), Gsc (f, n) and Brachyury (g, o) probes at stage 10 (upper line) and 11 (second line) as indicated. h', i', j', k', l', n' and o' are midline sagittal sections through the embryos shown in h, i, j, k, l, n and o respectively. Scale bar: 500 µm. B) Summary of the three main expression territories identified at stage 11 on the basis of gene expression patterns. Left panel: transcript distribution in the upper cell layer of the blastoderm. Right panel: transcript distribution in the lower layer of the posterior overhang. C) Phenotypes of Xenopus embryos injected with dogfish Otx mRNAs. Embryos at four-cell stage were dorsally-injected with 100 pg dogfish Otx mRNA. They were cultured to stage 35 for score of phenotypes. (a) An uninjected embryo. (b) A dogfish Otx1-injected embryo. (c) A dogfish Otx2-injected embryo. (d) A dogfish Otx5-injected embryo. Overexpression of all three dogfish Otx proteins leads to very similar phenotypes. D) Expression of mesoderm and cement gland markers in dogfsih Otx-injected Xenopus embryos. The embryos shown in the second, third and fourth column were respectively injected with 100 pg of dogfish Otx1, Otx2 and Otx5 mRNA, controls are shown in the first column. The embryos hybridized with Xnot2 (first line), chordin (second line) and Xbra (third line) were injected in the dorsal region at the four-cell stage and developed until stage 11, those hybridized with the XCG probe (fourth line) were injected in the ventral region and developed until stage 25. (a) Control embryo showing Xnot2 expression in the dorsal mesoderm. (b, c, d) Injection of dogfish Otx1 (b), Otx2 (c) and Otx5 (d) inhibits Xnot2 expression. (e) Control embryo showing chordin expression. (f, g, h) Injection of dogfish Otx1 (f), Otx2 (g) and Otx5 (h) did not affect chordin expression. (i) Control embryo showing Xbra expression in the entire maginal mesoderm. (j, k, l) Injection of dogfish Otx1 (j), Otx2 (k) and Otx5 (l) inhibits Xbra expression at the sites of injection. (m) Control stage 25 embryo showing XCG1 expression in the cement gland. (n, o, p) Injection of dogfish Otx1 (n), Otx2 (o) and Otx5 (p) strongly induced ectopic XCG1 expression in the ventral region.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847705-1-ponep0000374pg004.jpg"
} | 001176 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Expression profiles of signalling molecules in the dogfish from pre- to early gastrulation stages.a–n: animal views of dogfish embryos hybridized with Vg1 (a, f, k), Wnt8 (b, g, l), Nodal (c, h, m), Lefty (d, i, n), Bmp4 (e, j, o) probes. f', l', h', n', j' are sagittal sections through the embryos shown in f, l, h, n, j respectively, after eosin counterstaining. The planes of sections are indicated by thin lines on the whole-mount view of each embryo. h” is a higher magnification of h at the level of the posterior margin. Similarly the view in m is restricted to the posterior margin. Scale bar: 500 µm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847705-2-ponep0000374pg005.jpg"
} | 001177 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Histological sections of dogfish embryos from stages 10 to 14.For each stage, a schematic animal view of the embryo is shown on the left, anterior to the top. Dotted lines on this view indicate the level and plane of the sections shown. Sagittal sections are shown with anterior to the left and posterior to the right. Sections A2–A3, B3, C3–C4, C6–C7 are respectively higher magnifications of sections A1, B1, B2, C2, C5. Sections A1–A3, B1–B3, C1–C4, D1–D7, E1–E4 are stained with hematoxylin/eosin. Section B4 shows a high magnification of central posterior margin stained with rhodamine-phalloidin and DAPI. Section C5 is stained with phalloidin. In B3 the arrowhead points to bottle-like cells and the asterix shows the location of elongated cells close to the posterior margin. Scale bar: 500 µm. Abbreviations: ar, archenteron; bl, blastocoele; e, endoderm; m, mesoderm; me, mesendoderm; y, yolk.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847705-4-ponep0000374pg001.jpg"
} | 001178 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Early polarities at blastula stages in the dogfish.A. a–f: animal views of early dogfish embryos hybridized with Otx5 (a,d) , Bmp4 (b, e) and Nodal (c, f) probes. g: double in situ hybridization using Bmp4 (blue) and Otx5 (brown) probes at stage 9. h: sagittal section through a stage 7/8 dogfish embryo stained with rhodamine-phalloidin (red) and DAPI (blue). At this stage, the embryo consists in a mass of round-shaped cells lying on top of the vitellus. A single layer of elongated cells is visible at the level of the blastocoele roof. Scale bar: 500 µm. B. Abnormal expression of anterior markers in Bmp4 null mutant embryos. Lateral views of wild-type (WT: a, c) and Bmp4tm1Blh/Bmp4tm1Blh (Bmp4-/- :b, d) 6.5 dpc mouse embryos, hybridized with Otx2 (a, b) and Dkk1 (c, d) probes. In Bmp4-/- embryos, Otx2 transcripts are not restricted anteriorly and a distal extension of the Dkk1 territory in the anterior visceral endoderm is visible. e: Higher magnification of the embryo in e, showing the absence of Otx2 transcripts in the distal part. Scale bar: 100 µm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847705-5-ponep0000374pg006.jpg"
} | 001179 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Rapamycin does not block Rheb-mediated synapse growth.Panels A–C show anti-CSP staining of NMJ synaptic boutons, demonstrating that the TORC1 inhibitor rapamycin does not block synapse growth in control animals or in larvae with neuron-directed expression of Rheb (elav-Gal4>UAS-Rheb). Panels D and E provide quantification of bouton numbers/muscle area and numbers of motoneuron branches, respectively, for elav-gal4 controls (n = 44), animals with neuronal expression of Rheb (n = 41), control animals treated with rapamycin (n = 26), and Rheb expressing animals treated with rapamycin (n = 29). The scale bar is 50 microns.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847706-0-ponep0000375pg003.jpg"
} | 001180 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Photoreceptor axon projection defects associated with increased Tor signaling.(A–D) Dorsal-posterior views of third instar optic lobes stained with MAb24B10 to visualize photoreceptor projections. (A) Mitotic clones in an FRT82B control background show proper termination of photoreceptor axons R1-6 at the lamina plexus (LP), and termination of photoreceptors R7 and R8 in the medulla (Med). (B) Tsc129 mutant axons terminate at incorrect positions above and below the lamina (arrowheads) and produce a broadened lamina plexus. (C) Neuronal expression of Rheb creates axon termination defects similar to those seen in Tsc1 mosaics (D) Ptendj189 mutant photoreceptors leave gaps and holes (arrowhead) in the lamina plexus, which is broader and noticeably “peaked.” The medulla contains axon projections which are thicker and much longer than in controls (arrow). (E–H′) Dorsal view of optic lobes from 40h pupae stained with MAb24B10. E′–H′ are lower optical planes of the optic lobes shown in E–H, respectively. (E, E′) Control photoreceptors R7 and R8 show two distinct layers of termination in the medulla (labels), and are arranged in a highly regular pattern (arrowhead). (F) Animals with Tsc129 mutant photoreceptors show severe disruption of the R7 and R8 termination layers. Instead of terminating at the correct positions, the axons fail to de-fasciculate, forming dense bundles (arrowheads) that project beyond the medulla. (G, G′) Neuron-directed expression of Rheb causes axon bundles to project beyond the medulla in a fashion similar to Tsc1 mosaics (arrowheads), but the phenotype is much less severe. (G, inset) Individual Rheb-overexpressing axons show an intermediate termination defect, stopping several microns beyond their normal targets (arrowheads in inset). (H) Ptendj189 mutant axons exhibit gaps and collapses in the R7/R8 termination zone (arrowhead). Thick axon bundles can be seen that bypass their usual stopping points and then loop back to terminate at other locations in the R7/R8 layers (arrows). (H′, F′) Axon bundles in Ptendj189 mosaics are not as densely packed as those of Tsc129 mosaics (arrowheads), but are still disorganized. All scale bars are 50 microns.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847706-2-ponep0000375pg005.jpg"
} | 001181 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Effects of mutations that downregulate the Tor pathway on photoreceptor axon guidance, and genetic epistasis with Tsc1.Optic lobes from third instar larvae (A–C) and 40h pupae (D–F) stained with MAb24B10. (A) Larvae heteroallelic for a hypomorphic combination of Rheb alleles show abnormal photoreceptor patterning and contain thick axon bundles that extend into the medulla (arrowhead). (D) At the 40 h pupal stage, Rheb mutants display axons that bypass their normal targets in the R7/R8 termination zones (arrowhead). (B) Larvae homozygous for a hypomorphic Tor allele show fairly normal photoreceptor patterning, but at the pupal stage (E) misrouted axons can be seen in the medulla (arrowheads). (C) S6k null homozygous larvae show thick axon bundles projecting past the lamina (arrowhead), while S6k pupae (F) display misrouted axons that initially bypass the R7/R8 termination zone (arrowhead). (G, H) Animals doubly mutant for Tor and Tsc1 do not show the severe photoreceptor defects seen when axons are mutant for Tsc1 alone (compare to Figure 5B, F, F′), although mild defects similar to those in Tor mutants are still apparent (arrowhead). (I) S6k-Tsc1 double homozygous mutants display a severe phenotype dissimilar to mutants for either S6k or Tsc1 alone. The scale bar is 25 microns in panel A, 50 microns in panel D.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847706-5-ponep0000375pg006.jpg"
} | 001182 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Axon guidance defects in Tsc1 mosaics are not suppressed by blocking growth.(A–C) Third instar eye discs from wild type and Tsc1 mosaic larvae raised with or without rapamycin (rap). Ommatidial units, comprised of eight photoreceptors, were visualized with phalloidin (red) that detects F-actin, and MAb24B10 (green). Phalloidin staining is strongest at the perimeter of each ommatidium, outlining each sensory unit. Rapamycin treatment of Tsc1 mosaic eye discs (C) restored eye disk size and cell size compared to wild type (A). (D and E) Rapamycin treated third instar larval brains stained with MAb24B10. Rapamycin treatment blocked abnormal growth of the retina and the increase in photoreceptor cell size, but did not ameliorate the abnormal axon projections also characteristic to untreated Tsc129 mosaics. The scale bars in panel A represent 50 microns in the left image, 10 microns in the right image. The scale bar is 50 microns in panel D.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847706-6-ponep0000375pg007.jpg"
} | 001183 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Male tail phenotype resulting from mutations in lon-8. (A), (B), DIC micrographs of ventral views of representative male tails of him-5(e1490) and lon-8(hu187) animals. Bar is 20 μm. Whereas rays 1–9 can clearly be distinguished in wild type males, in lon-8 males they are clumped together as an amorphous mass. (C)-(F) DIC and fluorescence micrographs of approximately 40 hour old him-5(e1490) males expressing lon-8::gfp in the lateral and ventral part of the tail hypodermis. These are, from 1–7: V6.pppaa, T.aa, R6.p, T.apapa, R7.p, R8.p and R9.p. \"Set\" indicates the male tail seam. (C)-(D) left lateral view, (E)-(F) mid-plane view.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847802-2-1471-213X-7-20-6.jpg"
} | 001184 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Expression pattern of a lon-8 transcriptional reporter. (A) Schematic representation of the reporter construct (see text for details). The portion of the first exon that is removed is indicated with a dashed line. The gfp coding sequence is shown in green. (B) to (G) Differential interference contrast (DIC) microscopy and corresponding fluorescence micrographs. Bar is 20 μm. (C) A comma stage embryo expressing lon-8::gfp in the nuclei of hyp4. (D), (E) A 1.5 fold stage embryo expressing lon-8::gfp in hyp4 and hyp7 nuclei. (F), (G) An L1 larva expressing lon-8::gfp in hyp4 and the hyp7 syncytium.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847802-6-1471-213X-7-20-3.jpg"
} | 001185 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Early expression of sdf1a and primordium migration. A: At 22 hpf a thin stripe of cells along the horizontal myoseptum begins to express sdf1a. Dotted outline of the primordium derived from panel B. B: in the same embryo but in a slightly more superficial focal plane the primordium extends posteriorly and overlays the tip of the sdf1a stripe.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847803-1-1471-213X-7-23-6.jpg"
} | 001186 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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{
"caption": "Early expression of cxcr7. A: no expression can be detected in the placode or in the primordium that begins to elongate towards the first somite at 20 hpf. B: expression can first be detected in trailing cells (arrow) when the primordium begins to extend along the myoseptum. C: expression increases (arrow) as the primordium extends along somites 1–3.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847803-6-1471-213X-7-23-4.jpg"
} | 001187 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Early expression of cxcr4b. A: expression is first detected in a cluster of placodal cells (arrow) in 19 hpf embryos. B: expression is much enhanced in 20 hpf embryos. C: by 22 hpf the primordium has made contact with the SDF1 trail and elongates into somite 1. D: at about the same time cxcr4 expression is down-regulated in a small cluster of cells near the presumptive trailing edge of the primordium (arrow).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_109-PMC1847803-9-1471-213X-7-23-5.jpg"
} | 001188 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Abdomen CT shows 9 × 8 cm-sized multiseptated cystic lesion with inner calcification in the spleen.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC545954-0-1471-2407-4-96-1.jpg"
} | 001189 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "The section reveals papillary hyperplasia of mucinous lining epithelium with stratification and atypism (H&E stain, ×250).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC545954-1-1471-2407-4-96-2.jpg"
} | 001190 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Photomicrograph of cirrhotic liver stained with Perls' technique. Liver of a 50 year-old African American woman with a history of chronic alcoholism. There is a predominance of iron staining (grade 4) in hepatocytes, and prominent staining of bile ductule cells. Micronodular cirrhosis and moderate-severe steatosis were also present. Original magnification 100×.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546193-1-1472-6890-5-2-4.jpg"
} | 001191 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Photomicrograph of non-cirrhotic liver stained with Perls' technique. Liver of a 44 year-old African American man who died of pneumonia. There is a predominance of iron staining (grade 4) in hepatocytes. Original magnification 40×.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546193-3-1472-6890-5-2-1.jpg"
} | 001192 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Off axis 2-D short axis TEE view with the probe advanced further into mid-esophagus: demonstrates turbulent color flow entering the LA from the EL region of the aortic valve illustrated in Fig 1",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546197-1-1476-7120-3-1-2.jpg"
} | 001193 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Off axis 2-D short axis TEE view demonstrates the left atrium (LA) the prosthetic aortic valve (AV). An echolucent area (EL) around the aortic valve protruding into LA is seen with focal outpouching into the LA. This represents weakening of the wall of the aorta near the posterior aspect of the LA",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546197-2-1476-7120-3-1-1.jpg"
} | 001194 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Scanning electron micrograph survey of pumice granules and biofilm development. Before colonisation (A) pumice granules are blank. After 6 month of operation (B), rod shaped cells cover the pumice surface. In the 12 month biofilm, an abundant exopolymeric matrix is visible on pumice granules both at the bottom (C) and top (D) of the column.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546200-2-1475-2859-4-4-1.jpg"
} | 001195 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Scrib can recruit LPP to an ectopic location in vivo through its PDZ domains. CV-1 cells were transiently co-transfected with Xpress-hScrib-mito or Xpress-hScribdPDZ-mito, and GFP-fusions of wild-type full length human LPP, or LPP with a mutated carboxy-terminus (T610A). Xpress-hScrib-mito and Xpress-hScribdPDZ-mito are composed of the human full length Scrib protein with or without its PDZ domains, respectively, which is fused to an Xpress-epitope-tag at its amino-terminus, and to an ActA-derived mitochondrial membrane anchor at its carboxy-terminus, Cells were stained with an anti-Xpress antibody to detect Xpress-Scrib(dPDZ)-mito. Immunofluorescence and GFP were visualized by epifluorescence microscopy. The focal adhesion localization of the GFP-LPP proteins is not visible in these pictures because a focal plane corresponding to mitochondrial staining is shown.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546208-0-1471-2121-6-1-7.jpg"
} | 001196 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Scrib and LPP are localized in cell-cell contacts but are dispensable for targeting each other to these structures. Upper panels: MDCKII cells, grown on glass coverslips, were double labelled with anti-LPP antibodies (left panel) and anti-Scrib antibodies (right panel). Lower panels: MDCKII stable cell lines, expressing GFP-fusion proteins containing wild-type human LPP (upper left panel), LPP with a mutated carboxy-terminus (T610A) (upper right panel), human wild-type Scrib (lower left panel), or Scrib with a deletion of all its PDZ domains (lower right panel), were grown on glass coverslips (Scrib) or on Transwell-Clear polyester membranes (LPP). GFP-fluorescence was visualized by epifluorescence microscopy (Scrib) or by confocal microscopy (LPP).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546208-4-1471-2121-6-1-5.jpg"
} | 001197 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Scrib is not localized in focal adhesions in CV-1 cells, and is dispensable for targeting LPP to these structures. Upper panels: CV-1 cells, grown on glass coverslips, were double labelled with Scrib-472 antibodies (left panel) and anti-vinculin antibodies (right panel) used as a marker for focal adhesions. Lower panels: CV-1 cells were transiently transfected with wild-type human LPP (left panel), or LPP with a mutated carboxy-terminus (T610A) (right panel), as GFP-fusions. GFP-fluorescence was visualized by epifluorescence microscopy.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546208-5-1471-2121-6-1-4.jpg"
} | 001198 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
|
{
"caption": "Characterization of anti-Scrib antibodies. (A) Total cell extracts were prepared from the following cell lines: human embryonic kidney epithelial cells (293) (lane 1), dog normal kidney epithelial cells (MDCK) (lane 2), human T lymphocytes (Jurkat) (lane 3), and African green monkey kidney fibroblast cells (CV-1) (lane 4). Approximately 30 μg of protein from each extract was analysed by SDS-PAGE and Western blotting with the Scrib-472 antibodies. The position of molecular markers are as shown. (B) Total cell extracts of 293T cells, either not transfected (lane 2), or transiently transfected with Xpress-hScrib that is composed of the full length human Scrib protein fused to an Xpress-epitope-tag at its amino-terminus (lanes 1 and 3) were analyzed by SDS-PAGE and Western blotting with an anti-Xpress antibody (lane 1) or with the Scrib-472 antibody (lanes 2 and 3). The position of molecular markers are as shown. (C) MDCKII cells, grown on glass coverslips, were fixed and stained with Scrib-472-antibodies. Immunofluorescence was visualized by epifluorescence microscopy.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_0_11-PMC546208-6-1471-2121-6-1-3.jpg"
} | 001199 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00000.tar |
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