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{
"caption": "Example T1-weighted MRI images, and three-point Dixon MRI-obtained quantitative fat-fraction maps, from a healthy volunteer (top images), and a person with CMT1A (bottom images).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271780-0-fneur-13-930435-g0001.jpg"
}
|
009100
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Test-retest fat-fraction map images from an example healthy volunteer for the calculation of reproducibility metrics. Images were acquired at two time points, 2 weeks apart. The fat fraction map was calculated from three-point Dixon acquisitions using the MRI study protocol, and shown with the placement of the whole muscle ROIs overlaid on the slice. All images were windowed to the same range for display (0–100%).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271780-1-fneur-13-930435-g0002.jpg"
}
|
009101
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "(A) On the left, single plane image from in vivo reflectance confocal microscopy of digit V. (B) In the middle, the MCs are identified by yellow circles in a healthy control. (C) On the right, MCs are identified by yellow circles in an individual with CMT 1A.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271780-2-fneur-13-930435-g0003.jpg"
}
|
009102
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Manifestations of COVID-19-associated anti-MDA5 dermatomyositis. (A) Cutaneous manifestations presented as violaceous, maculo-papular lesions on both dorsal and volar sides. (B) Nailfold video-capillaroscopy illustrated reduced capillary density, neo-angiogenesis, and tortuous, ectasic and giant capillaries. (C) Anti-MDA5 antibodies detected by immunoprecipitation. (D, E) T1-weighted cardiac magnetic resonance images presenting increased signal intensity [native T1 = 1067 ± 37msec (NV < 1015)], which, in association with ECV = 30 ± 4% (NV < 29) and normal T2 intensity [native T2 = 46 ± 3 msec (NV < 50 msec)], indicates interstitial myocardial fibrosis and is consistent with previous myocarditis. (F) Skin punch biopsy of a Gottron-like lesion on the left hand showing patchy mixed superficial inflammatory infiltrated with leukocytoclastic vasculitis features (Hematoxylin and eosin, 20x magnification).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271786-0-fimmu-13-937667-g001.jpg"
}
|
009103
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Fundus findings before the IVIG treatment. Right (A) and left (B) wide-field fundus photographs show no abnormal findings.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271790-1-fped-10-943652-g0002.jpg"
}
|
009104
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Ophthalmological slit-lamp examination before and after the intravenous immunoglobulin (IVIG) administration. Right (A) and left (B) slit-lamp photographs show bilateral conjunctival, episcleral and scleral njection, suggesting scleritis and concomitant conjunctivitis. Right (C) and left (D) slit-lamp photographs after IVIG administration, showing the dramatic improvement in their ocular findings.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271790-2-fped-10-943652-g0001.jpg"
}
|
009105
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Outline of manual vs. automated techniques for estimation of net water uptake from baseline (top panels) and follow-up (bottom panel) CT scans of stroke patients. The RAPID core output (A) from CTP processing is used to determine the ASPECTS regions to be used for manual estimation of NWU from baseline NCCT (B). Regions-of-interest (ROIs) are placed in these regions within the affected hemisphere (orange) and matched ROIs are placed in the contralateral hemisphere (purple). Manual NWU is calculated as one minus the ratio of mean densities of the two sets of ROIs. For automated measurement of NWU on baseline CTs, CBF maps (C) are generated from raw CTP data (as fully detailed in the Supplementary Methods and shown in Supplementary Figure 1). The core mask (defined by thresholding at CBF < 30% of normal) is then registered and overlaid onto the NCCT (blue region in D). This infarct region is then flipped across the midline (purple region; method fully outlined in the Supplementary Methods and shown in Supplementary Figure 2) to create a matching mirror region (E). Automated NWU is calculated as one minus the mean densities of these two regions, after removing voxels of CSF (from separate CSF segmentation) or with HU density below 20 or above 80 from both regions (removed voxels shown in white). Lower panels show similar workflow for follow-up CTs (or baseline CTs with visible hypodensity). ROIs are placed within ASPECTS regions within the visible infarct and matching ROIs are placed in the contralateral hemisphere to calculate manual ROI-based NWU (F). The infarct region is also manually segmented (yellow, G). A deep learning-algorithm is applied to automatically segment regions of hypodensity and generate an infarct mask (blue, H). Infarct regions are then flipped to create matching mirror ROIs (purple, I). Regions of CSF are then removed, as are voxels outside the thresholds (HU 0–40 for infarct, 20–80 for normal brain). Automated NWU is then calculated. In this example, manual NWU on baseline CT was 16.0 and automated NWU was 12.3. For follow-up CT, the manual infarct volume was 135 ml and the automated volume was 143 ml. The manual NWU was 29.8 using ASPECTS ROI-method, 25.4 using the whole manual infarct, compared with 25.0 for the fully automated NWU.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271791-0-fneur-13-898728-g0001.jpg"
}
|
009106
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Example of follow-up CT in a patient who developed a focal parenchymal hematoma within the region of infarction. (A) Original non-contrast CT with regions-of-interest manually placed within the infarct (avoiding hemorrhage) and in contralateral matching regions (avoiding CSF); (B) Blue region indicates automated segmentation of infarct lesion; (C) Processing of follow-up CT to measure NWU using automated infarct mask, with removal of voxels representing CSF (white regions within purple normal mask) and voxels outside the range of 0-40 HU (removing most regions of hemorrhage). The manual NWU was 21.0 and the fully automated NWU was 21.6.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271791-2-fneur-13-898728-g0004.jpg"
}
|
009107
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Group differences in deformation-based morphometry (DBM) indexes between HIV infected (HIV+) and HIV uninfected (HIV-) group. (A) Bilateral superior and left middle frontal regions showed decreased DBM indexes (i.e., tissue atrophy) in the HIV+ group (voxel-level uncorrected P < 0.001, cluster level P < 0.05, FWE corrected). (B) Right cerebellum showed increased DBM indexes (i.e., tissue enlargement) in the HIV+ group (voxel-level uncorrected P < 0.001, cluster level P < 0.05, FWE corrected). The colors indicate the t-statistics.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271794-0-fneur-13-909437-g0001.jpg"
}
|
009108
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Functional alterations of the deformed brain region in the HIV+ group. Functional connection between the deformed right superior frontal region (in green color) and the right inferior temporal gyrus (in red color) was significantly increased in the HIV+ group (voxel-level uncorrected P < 0.005, cluster level P < 0.05, FWE corrected).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271794-2-fneur-13-909437-g0002.jpg"
}
|
009109
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Enhanced magnetic resonance imaging (MRI) on the 3rd admission day. Axial (A) and (B) and coronal T1-weighted images (C) showing that the abscesses were located in the right iliacus muscle (▴) and posterolateral to the right psoas (※).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271797-0-fsurg-09-871292-g001.jpg"
}
|
009110
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "TMEM33 promotes cell proliferation in cervical cancer. (A,B) CCK-8 assay of HeLa and SiHa cells transfected with TMEM33 siRNA. (C,D) Colony formation assay of HeLa and SiHa cells transfected with TMEM33 siRNA. (E,F) DNA synthesis determined by EdU incorporation assay after cell transfection with TMEM33 siRNA in HeLa and SiHa cells (EdU% represents the proportion of EdU-positive cells [orange]). Data are mean ± SD of three independent experiments *p < 0.05, **p < 0.01, and ***p < 0.001.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271802-4-fgene-13-908807-g007.jpg"
}
|
009111
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Cytoskeleton architecture and stem cell proliferation. (A) Stem cell cytoskeleton architecture. Cell nuclei were stained with 0.5 mg/ml DAPI. Cytoskeleton analysis by Phalloidin TRITC staining was carried out in hASCs grown on the Bio-Oss®/Avitene biomaterial (magnification 20 × ). Actin filaments show no alteration in structural organization, confirming the compatibility of the assayed biomaterial, at day 6. (B) Human adipose stem cells (hASCs) metabolic activity was evaluated by colorimetric intensity at day 0, 3, 6 and 9 of co-culture on the Bio-Oss®/Avitene and culture polystyrene (TCPS) vessels. The biomaterial showed an increase of cell metabolic activity at 3, 6 and 9 days compared to day 0 (°p<0.01). hASCs grown on the scaffold showed a statistical increase of cell metabolic activity at day 9 compared to days 3 and 6 (#\np < 0.01). The metabolic activity measured by AlamarBlue® assay demonstrated different cellular growth kinetics, which are statistically significant at day 3, 6 and 9 compared to cell proliferation on the TCPS control group at day 0 (*p < 0.001). Experiments were performed in technical triplicate for each biological sample (n = 3).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271820-0-fbioe-10-873814-g001.jpg"
}
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009112
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Biomaterial induced matrix mineralization. (A) hASCs grown on scaffolds were stained with AR and imaged with bright-field microscopy at day 21 (10× magnification upper figures, 4× magnification lower figures). The biomaterial induces mineral matrix deposition better than the plastic vessel (TCPS), the control. (B) The quantification of AR was performed by eluting AR staining and acquiring optical density measurements. Osteogenic differentiation of hASCs grown on the biomaterial was increased compared to TCPS (*p < 0.05). In OC, the calcium deposits were higher than in cells grown on the scaffold and in TCPS (***p < 0.0001). Experiments were performed in technical triplicate for each biological sample (n = 3).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271820-1-fbioe-10-873814-g003.jpg"
}
|
009113
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Representative cholangiogram at the supine position from a 66-year-old female patient who had presented with persistent pain for the previous 10 h, showing: the accessory cystic duct (arrow) draining into the right hepatic bile ductal system (A); between the inflow accessory cystic duct (right arrow) and outflow cystic duct (left arrow) of contrast agents demonstrated double cystic duct (B).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271822-0-fsurg-09-892927-g003.jpg"
}
|
009114
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Magnetic Resonance Cholangiopancreatography (MRCP) shows the gallbladder to be filled with stones. The cystic duct is low confluence to common bile duct (CBD) in MRCP.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271822-1-fsurg-09-892927-g002.jpg"
}
|
009115
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Representative coronal plane enhanced computed tomography (CT) image from a 66-year-old female patient with persistent pain for the previous 10 h, showing a typical-looking inflamed gallbladder (arrow) with marked distention and wall thickening.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_47-PMC9271822-2-fsurg-09-892927-g001.jpg"
}
|
009116
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Clustering of digital levels. (A) Original image, (B) clustered image, (C) Time evolution of digital levels.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271830-11-fphys-13-878391-g001.jpg"
}
|
009117
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Fascin-1 interacted with TAZ and mediated the entry of TAZ into the nuclei of microglia in vivo. (A) Coimmunoprecipitation (Co-IP) analysis of the interaction between Fascin-1 and TAZ in myelin-treated microglia and 7 days SCI tissues. IP, immunoprecipitation; Input, total cells and tissue lysate; WB, Western blot analysis. IgG was used as a control IP. Pull down of the endogenous Fascin-1 protein complex was performed using mouse monoclonal Fascin-1 antibody. Fascin-1 and TAZ proteins were detected after Western blot the resulting immunoprecipitates using the rabbit polyclonal Fascin-1 antibody, rabbit monoclonal TAZ antibody. (B) Immunofluorescence markers from the sagittal section of the spinal cords showed the spatio-temporal distribution of Fascin-1 (red), TAZ (green), and DAPI (blue) at pre, 7 and 14 days after SCI. White arrows indicated that TAZ accumulated the nuclei of Fascin-1+ microglia. The asterisks indicated the centre of the lesion. Scale bars: low magnification, 100 μM; higher magnification, 20μM.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271831-1-fphar-13-938416-g007.jpg"
}
|
009118
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Fascin-1 upregulated TAZ and mediated TAZ into the nuclei of microglia in vitro. (A) Western blot was used to detect the expression levels of Fascin-1 and TAZ after transfection with siFascin-1 (knockdown) and siNC (control) (n = 3 per group). (B,C) Quantitative analysis of the relative levels of Fascin-1 (B) and TAZ (C) as shown in (A). Protein expression was normalized to GAPDH. Data were mean ± SEM. *p<0.05 (siNC vs. siFascin-1#2) in (B); **p<0.01 (siNC vs siFascin-1#3) in (B); *p<0.05 (siNC vs. siFascin-1#2 or siFascin-1#3) in (C). The results showed that knockdown siFascin-1#3 was the best effect on transfection. (D) After transfection of siFascin-1 and siNC into microglia in vitro, double immunostaining analysis of TAZ (green) and Fascin-1 (red) in microglia. Scale bars: low magnification, 100 μM; higher magnification, 20 μM. Yellow arrows indicated that TAZ gathered around the nuclei of microglia. (E) Western blot was used to exam the expression levels of Fascin-1 and TAZ after transfection with plasmid Flag-Fascin-1 (overexpression) and Flag (control) (n = 3 per group). (F,G) Quantitative analysis of the relative levels of Fascin-1 (F) and TAZ (G) as shown in (E). Data were mean ± SEM. **p<0.01 (Flag vs Flag-Fascin-1) in (F). *p<0.05 (Flag vs. Flag-Fascin-1). (H) Double immunostaining analysis of TAZ (green) and Fascin-1 (red) in microglia after transfection with Flag and Flag-Fascin-1. White arrows indicated that TAZ accumulated the nuclear of microglia. Scale bars: low magnification, 100 μM; higher magnification, 20 μM.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271831-2-fphar-13-938416-g006.jpg"
}
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009119
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "TAZ was significantly increased and localized in microglia. (A) Western blot analysis of TAZ expression in spinal cords at 3d, 7d, 14d, and 28d after SCI, compared with Pre (pre-operation, Pre). (B) Quantitative analysis of TAZ level as shown in (A). The blots (n = 3 per group) were quantified by a densitometric method using ImageJ software. GAPDH was used as the loading control. Data were mean ± SEM. *p<0.01(Pre vs. 3d or 28d); ***p<0.001 (Pre vs. 7d or 14d). (C) Immunofluorescence labeling in sagittal section of spinal cords showing the spatiotemporal distribution of Iba1 (red), TAZ (green), and DAPI (blue) at Pre, 7d and 14d after SCI. White arrows indicated that TAZ aggregated in the nuclei of Iba1+ cells. The asterisks indicated the centre of the lesion. Scale bars: low magnification, 100 μM; high magnification, 20 μM.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271831-3-fphar-13-938416-g001.jpg"
}
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009120
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "The changes of TAZ after the polarization of microglia and myelin treatment. (A) Western blot was used to detect the changes of TAZ expression in the different microglial phenotypes and myelin treatment (n = 3 per group), microglia were differentiated into pro-inflammatory M1-like (M1-L), anti-inflammatory M2-like (M2-L), and resting, unstimulated (M0-L) phenotypes. (B) Quantitative analysis of TAZ expression in (A). GAPDH was used as the loading control. Data were mean ± SEM. *p<0.05 (M0-L vs. M2-L); **p<0.01 (M1-L vs. M2-L); **p<0.01 (M0-L vs. Meylin); ***p<0.001 (M1-L vs. Meylin). (C) Representative immunofluorescence images of TAZ (green) in M0-L, M1-L, M2-L microglia and myelin-treated microglia, and the nuclei were stained with DAPI (blue). Yellow arrows indicated that TAZ gathered around the nuclei of microglia. White arrows indicated that TAZ accumulated the nuclei of microglia. Scale bars: low magnification, 100 μM; higher magnification, 20 μM.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271831-8-fphar-13-938416-g003.jpg"
}
|
009121
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Histological sections stained with Giemsa-Eosin depicting (A) osseous interaction with the implant at the bone-implant interface, (B) bone ingrowth into small pores and cavities of the scaffolds, and (C) lymphocytic inflammation with infiltrating cells (arrow heads) primarily around “ELR only” coating and “Pre-mineralized” scaffolds. Newly formed bone in the histology images have been pseudo colored and represented with green to show clear difference between immature (new) bone and scaffold. Scale bar = 200 µm. Scaffold (SC), Immature bone (IB), Lymphocytic inflammation (LI). (D) Estimation of IL-10 concentrations secreted from macrophages after 3 and 6 days of culture on different test samples. * represents significant difference p < 0.005, estimated using two-way ANOVA in GraphPad Prism ver. 6 software.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271852-1-fbioe-10-836386-g004.jpg"
}
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009122
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "In vivo characterization. (A) Schematic of the study plan and view of the rabbit calvarial bone defect before and after implantation. Micro CT images of new bone formation in [(B), left] the positive control (Bio-Oss) and [(B), right] “Pre-mineralized” scaffold and [(C), left] “ELR only” and [(C), right] “Uncoated” scaffolds. (D) Normalized volume of newly formed bone with different test samples after 0, 3, and 6 weeks of implantation. Histological sections stained with Giemsa-Eosin depicting new bone formation marked with green colour after 6 weeks of implantation including (E) positive control (Bio-Oss), (F) “Uncoated” nylon scaffold, (G) “ELR only” coated nylon scaffold, and (H) “Pre-mineralized” scaffold. Scaffold (SC), Fibrous connective tissue (FCT), Immature (IB) and Mature (MB) bone. In (D) * represents significant difference p < 0.05 in normalized bone volume between sample groups and at different time points, estimated using two-way ANOVA in GraphPad Prism ver. 6 software.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271852-2-fbioe-10-836386-g003.jpg"
}
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009123
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "The result of wound healing (A–D) and transwell assay (E–J) in HCT-116 and SW480 CRC cell lines. **P < 0.01, ***P < 0.001, ****P < 0.0001.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271859-6-fimmu-13-910582-g006.jpg"
}
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009124
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Diagram of transected peripheral nerve wrapped with free denervated muscle graft.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271873-0-fsurg-09-819608-g006.jpg"
}
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009125
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Intrinsic functional connectivity correlates of associative memory enhancement. (Upper panel) Clusters identified in the functional connectivity MVPA as being significantly associated with associative memory enhancement. (Lower panels) Whole-brain correlation maps between seed connectivity and associative memory enhancement. Bar graphs show the percentage of overlap between the areas identified in the correlation maps and canonical functional networks of the cerebral cortex (Yeo et al., 2011). Note that the voxel-wise intensity threshold for the correlation maps corresponds to | t| = 3.12 (p ≤ 0.001).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271876-1-fnbeh-16-910180-g003.jpg"
}
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009126
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Lung histopathological changes.Groups of 4 animals were intranasally infected with 104 TCID50 of virus and sacrificed at 5 dpi. Based on severity of inflammation, alveolar hemorrhagic necrosis and vessel lesions, a cumulative score from 0 to 10 was calculated and assigned to a grade of severity (I, II, III and IV). a Experimental timeline. b Scoring of pathological changes (Details in Supplementary Data 4). Two-sided statistical analysis was performed using Shapiro–Wilk normality test, Fisher's exact test, and Student t-test. c Representative images of bronchial inflammation (scale bar: 100µ): severe peribronchiolar inflammation and bronchiole filled with numerous neutrophilic, marked peribronchiolar inflammation and normal bronchi. d Representative images of alveolar inflammation (scale bar: 100µ): severe infiltration of alveolar walls, alveoli filled with neutrophils/macrophages, marked infiltration of alveolar walls, some alveoli filled with neutrophils/macrophages and normal alveoli. e Representative images of vessel inflammation (scale bar: 100µ): moderate accumulation of inflammatory cells in arteriolar walls and normal arteriole.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271885-4-gr4.jpg"
}
|
009127
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Downregulated expression and Kaplan–Meier survival analysis of IRF8 in HCC. (A) The expression of IRF8 in tumor and adjacent normal tissues was determined in multiple HCC cohorts based on the HCCDB database. (B) Western blot analysis of IRF8 protein expression in 12 pairs of human HCC and matched adjacent tissues. T, tumor; N, adjacent. (C) Quantitative PCR analysis of IRF8 mRNA expression in 20 pairs of HCC and matched adjacent tissues. (D) Immunohistochemical detection of IRF8 expression in HCC (n = 90) and adjacent tissues (n = 88). (E) Overall survival rates of 90 cases HCC patients with high or low IRF8 expression were evaluated by Kaplan–Meier analysis. (***p < 0.001)",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271887-0-MCO2-3-e149-g001.jpg"
}
|
009128
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Transcriptional activity and subcellular localization analyses of TaHsfA2-13. (A) Transcriptional activation of TaHsfA2-13 in yeast. Schematic representation of the full-length TaHsfA2-13 and truncated protein constructs in the pGBKT7 vector. Fusion proteins of the GAL4 DNA-binding domain (BD) and full-length TaHsfA2-13 or truncated TaHsfA2-13 with (301–368 aa) or without (1–300 aa) AHA domain were expressed in the yeast strain AH109. Transformants were spotted onto SD/-Trp and SD/Trp-/His-/Ade-media. The plates were incubated at 30°C for 3 days. The pGBKT7 and pGBKT7-P53 vectors were used as negative and positive controls, respectively. (B) Subcellular localization of TaHsfA2-13 in tobacco leaf epidermal cells. Bars = 20 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271894-3-fpls-13-922561-g003.jpg"
}
|
009129
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Qualitative difference between the 2D and 3D (tomosynthesis) mammography for breast cancer diagnosis (Zhou et al., 2019).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271903-0-frai-05-884749-g0006.jpg"
}
|
009130
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "(a) The emergency CT suggested that the space under the inner plate of the skull was widened on both sides, which was considered a subdural effusion; (b) axial T2 weighted MRI demonstrates bilateral subdural effusions (arrows); (c) sagittal T1-weighted MRI demonstrates sagging of the brain; (d) axial T1 weighted MRI demonstrates bilateral ventricles narrowing; (e) axial T1 post-gadolinium showing diffuse, mild pachymeningeal thickening, and enhancement (arrow); (f) MRI spine sagittal T2 sequence demonstrates a fluid collection within the posterior paraspinal soft tissue.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271921-1-fneur-13-923529-g0001.jpg"
}
|
009131
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Pinching using artery forceps showing a complete analgesia of the prepuce in male camel post-epidural injection of romifidine (RO) (50 μg/kg).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271924-3-fvets-09-891581-g0001.jpg"
}
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009132
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Seizure occurrence and pathoanatomical changes relative to disease stages in glioblastoma. The different stages of glioblastoma progression are associated with their own relationship to seizure occurrence, of which focal and focal-to-bilateral are the most common semiology. When the bulk tumor is present (glioblastoma), the area where tumor meets “normal brain” is known as the peri-tumoral border (in red). The network organization of this area changes progressively with disease evolution. Upon resection, the peri-tumoral border is now termed the peri-cavity area. Now independent of the glioblastoma, this area may become intrinsically epileptic. When the tumor recurs, areas of the peri-cavity area now merge with the new peri-tumoral border (orange/red). At the endstage of the disease, the peri-cavity area and peri-tumoral border are simultaneously present (orange/red). Therefore, there are a multitude of mechanisms generating seizure activity both in the new peri-tumoral border and the epileptic peri-cavity area.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271928-0-fnmol-15-903115-g0001.jpg"
}
|
009133
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Changes in seizure characteristics during disease progression and treatment. There are a multitude of mechanisms that alter seizure characteristics and phenotype in GBM. The molecular mutations and consequently activated signaling pathways change throughout its progression and as it enters new areas of the brain. Upon resection, these mechanisms are altered again and often accompanied by a period of seizure cessation. Seizures may then be produced in the peri-cavity region due to pre-existing network disruption or tumor regrowth, or in an entirely different region due to secondary epileptogenesis.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271928-2-fnmol-15-903115-g0003.jpg"
}
|
009134
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Histological observations of leaves and stems. (A) Anatomy of a leaf cross section from hybrid sweetgum. a,c,e,g,i,k Cross-section of a diploid leaf; b,d,f,h,g,l cross section of a tetraploid leaf. a–d 25 d; e–h 50 d; i–l: 70 d. Ade: adaxial epidermis; Abe: abaxial epidermis; PP: palisade parenchyma; Sp: spongy parenchyma; Pi: pith; Ph: phloem; X: xylem. Bars are 200 μm in a,b,e,f,i,j; they are 20 μm in c,d,g,h,k,l. (B) Anatomy of a stem cross section from hybrid sweetgum. a,c,e Cross section of a diploid shoot; b,d,f cross-section of a tetraploid shoot. a,b 25 d; c,d 50 d; e,f 70 d. Ct: cortex; Ep: epidermis; Pi: pith; Ph: phloem; X: xylem. Bars are 200 μm in a,b,e,f; they are 20 μm in c,d.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271929-8-fpls-13-924044-g002.jpg"
}
|
009135
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Glia, neurons, and microglia/macrophages all contribute to the increase in CSPGs after SCI, and to scar formation. To characterize the cellular sources responsible for the increase in CSPGs after lamprey SCI, serial horizontal sections spanning the lesion site were collected from each lamprey at 2 (left column) and 10 weeks (right column) post-TX and processed by ISH (in blue) to detect lectican mRNAs, using probe 1. After ISH, IHC was performed (in brown) to identify glia (C,D), neurons (E,F), and microglia/macrophages (G,H). (A,B) Sections labeled by ISH alone show expression of lectican mRNAs primarily in gray matter around the central canal, and to a more limited extent, in the lesion site. (C,D) The same sections shown in (A,B) are additionally stained for glia. Arrows point to doubly labeled glial cells in the lesion site. (E,F) The same sections show doubly labeled neurons in the lesion site (arrows). Arrowhead in (F) indicates CSF-contacting neurons (Zhang et al., 2014b). (G,H) The same sections show IB4-positive microglia/macrophage profiles in the lesion site; some are doubly labeled by lectican-ISH (black arrows). At 10 weeks (H), the numbers of IB4-positive microglia/macrophage profiles are increased, and some neurons also are labeled by IB4 (white arrows). The inset in (H) is an enlarged image of the small box showing a neuron doubly labeled by ISH and IHC.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271930-0-fnmol-15-918871-g0010.jpg"
}
|
009136
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Time course of lectican expression after SC-TX. To quantify the changes of the four lecticans after SCI, transverse sections just rostral to the TX were mounted alternately on four slides as described and ISH performed using probes LecA, LecB, LecC, and LecD, respectively (A). As in the horizontal sections, compared to non-injured SC (top row), all four lecticans are upregulated by 1-week post-TX, then gradually decline. Lectican A and C return to levels near or lower than those of ctr SC at 2 weeks, but levels of lectican B and D remain higher than control through all time points investigated. The increase in lectican D is the most marked. The central canal (cc) is expanded after SC transection. (B) Semi-quantification of staining intensity shows the changes in the four lecticans after SC transection. n = the number of animals in each group. Five to eight sections from each animal were analyzed. Error bars indicate SEM. The intensity level of each lectican after SCI is compared with its level in control SC and within the group in each time point. Significance probabilities: *p < 0.05; **p < 0.01; ***p < 0.001.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271930-1-fnmol-15-918871-g0008.jpg"
}
|
009137
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "CSPGs are present in lamprey spinal cord and contribute to perineuronal nets. (A) Labeling of CSPGs with antibody CS-56 in SC wholemount shows a perineuronal distribution (arrows). (B) Loss of CSPG labeling after treatment with ChABC. (C) Labeling of lectins by WFL in a transverse section of SC shows the ring structure of PNNs (arrows). (D–F) CSPG immunofluorescence in transverse sections of SC without treatment with ChABC. (D) Intact CSPGs labeled by CS-56. (E) Sparse staining of CSPG stumps with antibody 2B6. (F) Overlay of (D) and (E). (G–I) As in (D–F) but after treatment with ChABC. CSPGs were broadly distributed in gray matter (GM) and white matter (WM) of normal lamprey SC, but not inside the large Müller axons (MAs). A few SC neurons were labeled by 2B6 before ChABC treatment (arrows in E), indicating the neuronal distribution of unsaturated disaccharide CSPG core proteins. ChABC treatment dramatically reduced the CS-56 immunoreactivity (G), while staining for CSPG stumps was increased (H). (I) Overlay of (G) and (H).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271930-2-fnmol-15-918871-g0001.jpg"
}
|
009138
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Developmental expression of lamprey lecticans in the spinal cord. (A) ISH of lecticans in lamprey at different ages. Serial longitudinal (embryo only) or transverse sections from each animal’s SC at the level of the 5th gill were mounted alternately on four slides, as shown in the top row (row 1). Numbers in the rectangles present the order of the sections. ISH was performed on each of these slides using four different probes, LecA, LecB, LecC, and LecD, respectively. The developmental stage or size of the lamprey is indicated on the sections in column 1. The sections in each image are representative for that animal at that level, and thus are comparable between lecticans. Note that in the larva, lectican D predominated, whereas in the larval and adult stages, lecticans A and C predominated. The expression levels of all lecticans were relatively high at early larval stages, declined at later larval ages, and then increased again after metamorphosis to the adult stage. nc = notochord. (B) A cartoon showing the structure of a transversely sectioned lamprey SC. Ma = Mauthner axon; GAs = Giant axons; WM = white matter; GM = gray matter; N = neuron; cc = central canal. (C) Semi-quantification of staining intensity shows the changes in the four lecticans during development. “Intensity (%)” = 100 × the ratio between the number of pixels that are labeled by ISH, and the total number of pixels encompassed within the SC perimeter (see “Methods” Section).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271930-3-fnmol-15-918871-g0006.jpg"
}
|
009139
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Expression of lectican mRNAs in neurons and glia. Transverse sections of lamprey spinal cord are double labeled by lectican ISH, using probe 1 (A,B) and by anti-Hu, an antibody specific for neuronal cell bodies (C), or LCM29, an antibody for glial keratins (D) that labels glial cell bodies and processes. Arrows in (C) point to cerebrospinal fluid (CSF)-contacting neurons. (E,F) Overlayed images show the expression of lectican mRNAs in neurons (arrows in E and F) and glia (arrowheads in E and F). cc = central canal. Asterisks = giant axons (Müller axons in the ventromedial white matter and the more dorsolateral Mauthner axon).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271930-6-fnmol-15-918871-g0003.jpg"
}
|
009140
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Distribution of lectican mRNAs in lamprey CNS. ISH using probe 1 shows broad expression of lectican mRNAs in lamprey brain and spinal cord. (A) A horizontal section of an adult brain (Br) shows that lectican mRNAs are expressed in neurons and glia but only weakly in the ependyma (arrow), IV = 4th ventricle; s = subventricular zone; p = peripheral zone. Transverse sections of spinal cord (SC) from a larva (B) and an adult (C) show that lectican mRNAs are expressed in SC neurons (white arrows) and glia (black arrows) and that the level of lectican mRNAs is higher in adult SC than in larval SC. D = dorsal; V = ventral; cc = central canal.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271930-9-fnmol-15-918871-g0002.jpg"
}
|
009141
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Contrast-enhanced computed tomography of the abdomen and pelvis showing thick-walled, inflamed appendix and cecum (white arrows), surrounding fat stranding (red arrow), and mesenteric lymphadenopathy (green arrow)",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271932-0-cureus-0014-00000025840-i01.jpg"
}
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009142
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Inflammatory infiltrate in the peri-appendicular tissues, disrupting the muscular layer",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271932-1-cureus-0014-00000025840-i03.jpg"
}
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009143
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Medium power view of the appendix showing mucosal and submucosal inflammation",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271932-2-cureus-0014-00000025840-i04.jpg"
}
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009144
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Low power view of the wall of the appendix showing acute inflammation",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271932-3-cureus-0014-00000025840-i02.jpg"
}
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009145
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Subcellular location of MeSLAH4 proteins. MeSLAH4-eGFP or 35 s-eGFP driven by the 35S promoter were transiently expressed in rice mesophyll protoplasts. Green signals indicate eGFP and red signals represent mCherry fluorescence. The merged images include the green fluorescence channel (first panels) and the chloroplast autofluorescence channel (second panels). The corresponding bright field images are shown on the right. Bar = 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271942-1-fpls-13-932947-g003.jpg"
}
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009146
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Fluorescent images of MCF-7 cells after incubation with probe N4 (40.0 μm) in the absence and the presence of Cu2+ (40.0 μm).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271948-5-fnut-09-932826-g0006.jpg"
}
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009147
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "(A) Cranial CT, without contrast, axial cut, evidencing subgaleal hypoattenuating formation in the frontal region, noting in the same plane, but in intracranial and extra-axial situation, hypoattenuating lesion with expansive character associated with irregularities in the contours of the inner table of the adjacent frontal bone. (B) bone window, in the same plane of subgaleal and extra-axial lesions, evidencing in the frontal bone, especially in the internal table lytic destruction with bone discontinuity.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271968-0-fsurg-09-889463-g001.jpg"
}
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009148
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "(A) Skull CT, without contrast, axial section, evidencing frontal extra-axial lesion, in left paramedian situation and hypoattenuation in the white matter of the left frontal lobe; (B) brain MRI, T2/FLAIR, axial, shows better the extra-axial expansive formation, located in the left anterior frontal pole, rounded, with apparent capsule, promoting compressive effect on the adjacent parenchyma, besides evidencing in adjacent frontal lobe small intraparenchymal lesion surrounded by important edema; (C) MRI of the brain, T1 after axial contrast, with important peripheral enhancement of both the extra-axial lesion (including with important enhancement of the locoregional meningeal plane) and intra-axial; (D) (DWI, axial section) evidences important central restriction of the extra-axial lesion with corresponding signal loss on the ADC Map (E) being compatible with empyema/abscess.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271968-1-fsurg-09-889463-g002.jpg"
}
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009149
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Comparative study between MRI in axial, sagittal and coronal sections before and after the surgical approach.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271968-2-fsurg-09-889463-g004.jpg"
}
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009150
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "(A) Positioning for surgical approach and marking of the bicoronal incision, evidencing the protuberance of the forehead by progressive swelling. (B) Intraoperative image after craniotomy with emphasis on fistulous hole of communication with frontal sinus, enhanced.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271968-3-fsurg-09-889463-g003.jpg"
}
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009151
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Plain chest radiograph (A) on December 2021 and (B) on January 2022, in which the effusion significantly increased.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271986-0-gr1.jpg"
}
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009152
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Abdominal CT scan at 3-month follow-ups after the treatment course; the liver underwent a noticeable recovery compared to the first examination.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271986-1-gr6.jpg"
}
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009153
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Panel (A) is the liver condition before the course of tuberculosis regimens (November 2021), and panel (B) is the follow-up CT scan after 3 months of treatment (January 2022). Even though the lesions were visible in both pictures, we could appreciate the improvement in the second result.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271986-2-gr5.jpg"
}
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009154
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "Axial abdominal MSCT illustrated multiple nodules with distinct margins at both the right and left lobes of the liver.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271986-3-gr2.jpg"
}
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009155
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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{
"caption": "(A) Axial, (B) coronal, and (C) sagittal delayed phase abdominal MSCT depicted multiple nodules with distinct margins at the liver lobes, surrounded by ascites fluid collection within the abdominal and pelvic cavity.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271986-4-gr3.jpg"
}
|
009156
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Axial section of abdominal MSCT with contrast administration showed contrast enhancement pattern from (A) noncontrast, (B) artery phase, (C) vein phase, and (D) delayed phase.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271986-5-gr4.jpg"
}
|
009157
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Helminth parasites' eggs detected in this study by sedimentation and flotation method (A,C,E,G) and Mini-FLOTAC technique (B,D,F,H) using fresh and preserved samples respectively. (A,B) eggs of Synthesium tursionis and (C,D) eggs of Braunina cordiformis from Tursiops truncatus; (E,F) eggs of Pholeter gastrophilus from Stenella coeruleoalba; (G,H) eggs of Anisakis sp. from Stenella coeruleoalba.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271992-0-fvets-09-908486-g0001.jpg"
}
|
009158
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Eggs of Ogmogaster antarcticus\n(A,B) and Bolbosoma sp. (C,D) from Balaenoptera physalus obtained by sedimentation and flotation method (A,C) and Mini-FLOTAC technique (B,D).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271992-1-fvets-09-908486-g0002.jpg"
}
|
009159
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Effects of SFN on histopathological characteristics and inflammatory in colitis mice. (A) Representative H&E staining of colon tissues (magnification ×200, and ×400). (B) Colonic histological score. (C) Effects of SFN on the concentrations of IL-6, TNF-α, and IFN-γ in plasma were determined by ELISA at a concentration of pg/ml. All data are presented as the mean ± SD. P-value < 0.05 was considered to indicate statistical significance (*P < 0.05 and **P < 0.01 compared with Group A, #P < 0.05 and ##P < 0.01 compared with Group B).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271993-2-fnut-09-893344-g0002.jpg"
}
|
009160
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Deletion of microglia promotes the growth of axons in the damaged core. (A). Immunofluorescence staining was used to distinguish the different area and indicates the extent of the axon, 10 weeks after surgery-induced astrocyte scar (GFAP, green) and the axon (Tuj1, red), scale bar = 500 μm; a1-a2 shows the magnified area of interest, scale bar = 50 μm. (B). Statistics of Tuj1-mean integrated density in different groups (n = three repeats, mean ± SD, *p = 0.0233, significant difference at p < 0.05, unpaired t-test) (C). Schematic diagram of trace virus injection (AAV 2/9 rAAV-hSyn-EGFP-WPRE-SV40 polyA) (D). Fluorescence image of the central nervous system of C57BL/6N mice, where the green fluorescence (eGFP) shows the corticospinal tract projected from the cerebral cortex to the spinal cord, scale bar = 5 mm; d1-d3 shows the enlarged images of the area of interest, scale bar = 1 mm. (E). Statistics of distance from termination of the spinal cord fluorescence signal (arrows) to the scar boundary (dotted line) (n ≥ three repeats, mean ± SD, *p = 0.0141, significant difference at p < 0.05, unpaired t-test). (F). Weight changes in experimental animals after surgery. n = 10 repeats, mean ± SD, days 8–10, *p < 0.05, significant difference among means, paired t-test.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271995-0-fphar-13-881195-g003.jpg"
}
|
009161
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Reduced collagen I expression induced incompact astrocyte scar formation. (A). Representative confocal images for astrocyte scar (GFAP, green) and collagen I (collagen I, red) at different time points (1, 2, and 4 weeks post SCI) show collagen I merged with GFAP and separate collagen I. Scale bar = 500 μm. (B). Representative confocal images of the astrocyte scar border (GFAP, green) and collagen I (collagen I, red) core (post operation 1 week) show collagen I separately and collagen I merged with GFAP. Scale bar = 100 μm. (C). Representative confocal images for collagen I (red) co-localization with microglia/macrophages (Iba1, green), scale bar = 500 μm; d1-d2 shows the magnified area of interest, scale bar = 30 μm. (D). Representative western blots of collagen I expression levels in the injured part of the spinal cord from each group. (E). Quantitative analysis of collagen I expression; the integrated density ratio of collagen I and GAPDH was taken as the ordinate (n = 3 repeats, mean ± SD, *p < 0.05).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271995-1-fphar-13-881195-g004.jpg"
}
|
009162
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Deletion of microglia attenuated the activation of chronic astrocyte scar. (A) Experimental timeline for SCI surgery in C57BL/6N mice and the procedure of deleting microglia in chronic astrocyte scars. “Microglia Deletion” indicates the time when the PLX3397 feed was started. (B) Representative confocal images for chronic astrocyte scar changes caused by microglia deletion (GFAP, green), scale bar = 500 μm; b1-b2 shows the magnified area of interest, scale bar = 50 μm; b3 shows the morphology of the cells selected in the dotted box of b1; b4 shows the morphology of the cells selected in the dotted box of b2. (C) Statistics of astrocyte (GFAP, green) quantity in the astrocyte scar border; the cell counting region was astrocyte scar, and a 2.5 × 105 μm2 region was taken from the center and edge of the spinal cord, n = 3 repeats, means ± SD, *p = 0.0097, significant different at p < 0.05, unpaired t-test. (D) Area of the damaged core (GFAP negative area of the injured area) was statistically compared (n = 3 repeats, mean ± SD, p = 0.7999, no significant difference, paired t-test).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9271995-2-fphar-13-881195-g005.jpg"
}
|
009163
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Aminor effect of propranolol on reactivated memories that were acquired with a single 1 mA shock during contextual fear conditioning. (A) Design of Experiment 2a. Mice received one 1 mA shock during fear conditioning. One day later, saline (n = 8) or propranolol (n = 8) was administered after memory reactivation. Forty-eight hours afterwards, retention of contextual fear was assessed. Cond, conditioning; MR, memory reactivation; Ret, retention; CS, conditioned stimulus (context);Sal, saline; Prop, propranolol. (B) Results of Experiment 2a. Average percentage of freezing during memory reactivation is displayed on the left, and freezing during the retention test on the right panel of the column chart (saline in white bars, propranolol in red bars). Error bars represent SEM. Filled circles indicate individual animals. (C) Results of Experiment 2b (saline, n = 9; propranolol, n = 9). Experiment 2b was a direct replication of Experiment 2a. (D) Collapsed results of Experiment 2a and Experiment 2b. (E) Representative images of the DG 90 min after the retention test from mice that received either saline (n = 7), or propranolol (n = 7) post-reactivation (Experiment 2a). Cells that were c-Fos+ are labeled in cyan (scale bar: 200 μm). (F) Number of c-Fos+ cells in the DG per 1.3 mm2. Error bars represent SEM. Filled circles indicate individual animals.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272000-2-fnbeh-16-893572-g0002.jpg"
}
|
009164
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Noeffect of propranolol on reactivated memories that were acquired witha single 0.7 mA shock during contextual fear conditioning.(A) Design of Experiment 1. Mice received one 0.7 mA shockduring fear conditioning. One day later, saline (n = 8) orpropranolol (n = 12) was administered after memoryreactivation. Forty-eight hours afterwards, retention of contextualfear was assessed. Cond, conditioning; MR, memory reactivation;Ret, retention; CS, conditioned stimulus (context); Sal, saline;Prop, propranolol. (B) Results of Experiment 1a. Averagepercentage of freezing during memory reactivation is displayed on theleft, and freezing during the retention test on the right panel ofthe column chart (saline in white bars, propranolol in red bars).Error bars represent SEM. Filled circles indicate individual animals.(C) Results of Experiment 1b (saline, n = 9;propranolol, n = 10). Experiment 1b was a direct replication of Experiment 1a. (D) Collapsed results of Experiment 1a and Experiment 1b. (E) Representative images of the DG 90 min after the retention test from mice that received either saline (n = 5), or propranolol (n = 5) after reactivation (Experiment 1a). Cells that were c-Fos+ are labeled in cyan (scale bar: 200 μm). (F) Number of c-Fos+ cells in the DG per 1.3 mm2. Error bars represent SEM. Filled circles indicate individual animals.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272000-5-fnbeh-16-893572-g0001.jpg"
}
|
009165
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Case 1: Parastomal varix in 47-year-old female. Patient presented with\nparastomal variceal re-bleeding after 178 days. Subsequently, a\ntransjugular intrahepatic portosystemic shunt stent (red arrow) was\nplaced resulting in interval resolution of parastomal variceal\nbleeding.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272059-0-10p1177_20584601221112618-fig7.jpg"
}
|
009166
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hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Case 1: Parastomal varix in 47-year-old female. Right portal venous\naccess was performed with subsequent selection of an SMV branch\ndemonstrating stomal varices (yellow arrow) in the region of stoma,\nidentified with stomal markers (blue arrow).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272059-1-10p1177_20584601221112618-fig1.jpg"
}
|
009167
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Case 1: Parastomal varix in 47-year-old female. Post embolization\nvenogram performed via a 5F pigtail catheter within the SMV demonstrates\ninterval resolution of parastomal varices.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272059-4-10p1177_20584601221112618-fig5.jpg"
}
|
009168
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Case 2: Parastomal varix in 61-year-old male. Right portal venous access\nwith sub-selective angiogram of a branch from the SMV supplying\nparastomal varices (orange arrow), with the stoma outlined via\nradiopaque markers (red arrow).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272059-5-10p1177_20584601221112618-fig2.jpg"
}
|
009169
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Case 1: Parastomal varix in 47-year-old female. Utilizing a 2.8 french\nprogreat micro catheter (via a C2 glide catheter) embolization of the\ntargeted stomal varices was performed with Glubran (cyanoacrylate glue)\ncombined with lipiodol (1:4 ratio glubran to lipiodol). Total of 0.5 cc\nof Glubran was administered.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272059-7-10p1177_20584601221112618-fig3.jpg"
}
|
009170
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Case 1: Parastomal varix in 47-year-old female. Embolization of the SMV\nbranch supplying stomal varices (yellow arrow) via an angled catheter\nwas performed. Embolization agents used: embozene particles (700 μm)\nfollowed by 1000 units of thrombin.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272059-8-10p1177_20584601221112618-fig4.jpg"
}
|
009171
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Cortex and subcortical white matter with concurrent ADNC and lesions of multiple sclerosis in autopsy cohort patient #1. Frontal lobe (A) with cortical amyloid plaques of AD (B) including ‘cotton wool plaques’ (arrows) and a dense-cored plaque (arrowhead), and subcortical chronic white matter plaque of multiple sclerosis (C) which is well-defined, with hypocellularity and loss of myelin (arrowhead) and preservation of adjacent myelinated axons (arrow). Temporal lobe (D) with cortical neurofibrillary tangle of AD (E) and subcortical multiple sclerosis plaque (F) with scattered reactive astrocytes and perivascular lymphocytic cuffing (arrow). Haematoxylin and eosin (x25) images (A, D), haematoxylin and eosin (x200) images (B, C, F), Bielschowsky silver (x200) image (E).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272064-2-fcac167f3.jpg"
}
|
009172
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Cardiac magnetic resonance imaging of the patient with both dyschromatosis symmetrica hereditaria (DSH) and Aicardi-Goutières syndrome type 6 (AGS 6). Cardiac MRI image indicated mitral valve stenosis (MS), severe mitral regurgitation (MR), tricuspid regurgitation (TR), biatrial enlargement with the more significant left atrium, biventricular hypertrophy, and a small amount of pericardial effusion (PE).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272138-1-fped-10-852903-g002.jpg"
}
|
009173
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Clinical features of the patient with both dyschromatosis symmetrica hereditaria (DSH) and Aicardi-Goutières syndrome type 6 (AGS 6). The symmetrical appearance of freckle-like pigmentation and hypopigmentation spots were on the face (A), backs of hands and feet (B,C), presenting a reticulate pattern. Enlarged cardiac shadow was observed through Chest radiographs, and the cardio-thoracic ratio was around 0.65. (D) Cardiac color ultrasound showed normal postoperative cardiac changes after patent ductus arteriosus closure, severe mitral regurgitation (MR) and moderate mitral stenosis (MS), extremely mild aortic regurgitation (AR), mild + tricuspid regurgitation (TR) and a small amount of pericardial effusion (PE). (E,F) Brain computed tomography revealed calcification in the dentate nucleus, basal ganglia and cerebral white matter and mild brain atrophy. The textures of both lungs were increased and blurred, and there were small patchy shadows (G). (H) A mitral valve biopsy revealed significant valve calcification, and the arrows marked the calcification.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272138-2-fped-10-852903-g001.jpg"
}
|
009174
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Breathing-induced differential gene expression in AXiAECS on-chip. (A) Timeline and schematic of the AXiAECs cultured in the AXLung-on-chip. Breathing was started at D5 on-chip. (B) Immunofluorescent stainings of AXiAECs in breathing and non-breathing (CTRL) conditions, fixed after 20 days culture on AX12 and stained with phalloidin to visualize F-actin fibers (red). Nuclei were stained with DAPI (blue). Scale bar = 20 µm. (C) Normalized gene expression of epithelial cell associated, alveolar type I cell specific and alveolar type II cell specific markers following 20 days of culture in AX12. Data shown as mean ± SEM (N = 2; n = 4), *p < 0.05, **p < 0.01, ***p < 0.001.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272139-2-ftox-04-840606-g005.jpg"
}
|
009175
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Expression of distinct alveolar epithelial cell markers in AXiAECs cultured on AXLung-on-chip. (A) Timeline and schematic of the AXiAECs cultured on the AX12. (B) Representative immunofluorescent staining for AXiAECs fixed after 7 days cultured in AX12 (D7), probed for epithelial: EPCAM (red), MUC1 (red); AT1-like: HTI-56 (green), HOPX (red). and AT2-like markers: SP-C (green), ABCA3 (red). Nuclei were stained with DAPI (blue). Scale bar is provided with each image. (C) Relative gene expression of distinct epithelial and (D) alveolar genes in A549 cells (N = 1; n = 3) and AXiAECs cultured on AXLung-on-chip (N = 2; n = 4) for 7 days. (E)\nAXiAECs stained for ACE2 (cyan) and TMPRSS2 (green). (F) qPCR results show gene expression of SARS-CoV-2 host factors in AXiAECs (N = 2; n = 4) after 7 days of culture in AX12. Data are shown as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272139-4-ftox-04-840606-g003.jpg"
}
|
009176
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Experimental paradigm and representative gaze patterns. (a) The free viewing experiment: at the start of each trial, the monkey fixates on a central fixation spot to initiate the trial. A pair of images, a face and an AGR of the same monkey (male or female), subsequently appear on each side of the screen for 3 s, after which they are replaced by a blank screen and a fixed amount of juice (0.5 ml) is delivered to the subject monkey independent of gaze behaviour during the trial. (b) Raw eye movement trace (blue) from one monkey in one example trial depicting fixations (i.e. nodes) and saccades (i.e. traces between nodes). (c) Raw eye movement traces from one monkey in one example session (female pictures, 120 trials). Each coloured line represents one trial. Cross: fixation spot; squares: image display windows. (d) Population heat maps of all monkeys' gazes in all saline sessions within the female (top row) and male (bottom row) face (left column) and AGR image displays (right column).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272140-0-rstb20210133f01.jpg"
}
|
009177
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "Total, nonspecific and specific OXTR binding in the human SN. (a) Total 125I-OVTA binding. (b) 125I-OVTA binding in the presence of 100 nM of OXTR antagonist ALS-II-69. (c) Digital subtraction of (b) from (a) to yield specific OXTR binding. (d) Nissl-stained tissue section showing the large, dopaminergic neurons of the pars compacta.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272142-0-rstb20210118f01.jpg"
}
|
009178
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "OXTR and TH mRNA expression in the human SN. (a) 4× microscope image of human SN tissue slice. Red box indicates location of (b) and (c). (b) 20× microscope image zoomed in from slice shown in (a). Red TH signalling indicated by red arrow; green OXTR indicated by black arrow. Cell nuclei appear purple, and the naturally occurring brown neuromelanin that is present in the dopaminergic neurons is also visible. (c) Macro created from image (b) for quantification; pink pixels represent TH mRNA and blue pixels represent OXTR mRNA. Scale bar of (a) is 750 µm, and scale bars of (b) and (c) are 50 µm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272142-2-rstb20210118f02.jpg"
}
|
009179
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "SEM images of cross sections of the Cu2O/PVP spherulites from broken particles. (a) Low magnification SEM image from 12 h sample, showing that the particle is constructed by needle-like components. A cavity at centre is visible. (b) SEM image from 12 h sample, showing a core at the centre of the spherulite. (c) High magnification SEM image from 1.5 h sample showing small spheres below 200 nm in diameter as building units of the needle-like components.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272154-1-d2ra03302j-f4.jpg"
}
|
009180
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "(a) TEM image of a fragment of a Cu2O/PVP spherulite from 1.5 h sample. The arrow indicates the radial direction in the spherulite. (b) The corresponding SAED pattern indexed to the cubic structure of Cu2O. (c) HRTEM image of a fragment of a spherulite from 12 h sample. The d-spacing of the double lines is about 2.15 Å, which can be indexed to the (200) planes of Cu2O. The [200] orientations of some nanocrystallites are indicated by the arrows and their angular off-alignment is marked.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272154-2-d2ra03302j-f5.jpg"
}
|
009181
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "SEM images of spherulites from the samples with reaction times of (a) 1.5 h and (b) 24 h. The arrows in (a) point to some broken particles with cross section displayed.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272154-5-d2ra03302j-f1.jpg"
}
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009182
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
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|
{
"caption": "SEM images of submicron sized spheres from (a) 15 min sample and (b) 45 min sample. (c) HRTEM of a submicron sized sphere from 15 min sample showing embedded nanocrystallites with d-spacings 2.14 Å marked, which can be indexed to the (200) planes of cubic Cu2O. Inset is the low magnification TEM image of the sphere where HRTEM images were recorded.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272154-6-d2ra03302j-f6.jpg"
}
|
009183
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "(a) Optical microscopy image of Cu2O/PVP spherulites with safranin T dye. The surrounding of spherulites shows blurred red, indicating the successful stain by safranin T. (b) Optical microscopy image of Cu2O/PVP spherulites with Congo red. The spherulites appear to be undyed, indicating the unsuccessful stain by Congo red.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272154-8-d2ra03302j-f7.jpg"
}
|
009184
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "nCLE image of discohesive cells, being identified as erythrocytes due to bleeding.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272180-0-10p1177_15330338221093149-fig3.jpg"
}
|
009185
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "nCLE image of prostatic tissue (A + C) and similarly appearing benign prostate glands and stroma in H&E stained histology slides (B + D), obtained from parallel trajectories, from the patient with Gleason score 4 + 3 = 7 prostate cancer in core needle biopsies.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272180-1-10p1177_15330338221093149-fig4.jpg"
}
|
009186
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "A 3-dimensional (3D) model of the prostate based on fused segmentations of prostate MRI and TRUS images. (A) Axial T2-weighted prostate MRI and (B) TRUS images were used for segmentation of the prostate and tumor (orange). (C) Registered trajectories of CLE measurements (red) and biopsies (blue) were annotated). Elastic fusion of prostate MRI and TRUS segmentations of the prostate, tumor, and trajectories resulted in a 3D model. (D) Corresponding regions of CLE measurement and biopsy trajectories were identified and used for coregistration of CLE images with histopathology.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272180-2-10p1177_15330338221093149-fig2.jpg"
}
|
009187
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "(A) An overview of a TTMB setting in the operating room including (B) a CLE measurement of the prostate with a forward imaging Cellvizio® AG-Flex 19 fiber optic mini probe-based system under transrectal ultrasound guidance using (C) sagittal and (D) axial planes. It was adapted from “The First In Vivo Needle-Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study” by Swaan et al, 2019, Lasers in surgery and medicine.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_48-PMC9272180-3-10p1177_15330338221093149-fig1.jpg"
}
|
009188
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "(A) USG showing bilateral increased renal echotexture. (B) Ultrasound showing a prominent left renal pelvicalyceal system with an 11 mm AP diameter of the renal pelvis",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272202-1-CCR3-10-e6010-g003.jpg"
}
|
009189
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "X‐ray erect abdomen showing normal findings",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272202-3-CCR3-10-e6010-g001.jpg"
}
|
009190
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Histologic images of postmortem kidney from patient who died with COVID‐19. (A, B) Showing glomerular nodular lesions and diffuse glomerular lesions. (C) Microscopic thromboses in the glomerulus, highlighted by CD 61 immunohistochemistry (inset). (D) Showing acute renal tubular injury. COVID‐19, coronavirus disease 2019; CD 61, cluster of differentiation 61",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272203-0-CCR3-10-e6024-g005.jpg"
}
|
009191
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Representative images of thoracic CT. (A) Two months before admission; Showing no interstitial pneumonia image. (B) Day 1 (on admission); Showing bilateral pleural effusions, findings of pulmonary edema and interstitial edema. (C) Day 27 (19 days after positive PCR); Showing slight ground‐glass opacity. (D) Day 34 (26 days after positive PCR); Showing revealed bilateral ground‐glass opacities and infiltrative shadows. (E) Day 56 (48 days after positive PCR); Showing bilateral pleural effusions and aggravated lung shadows with traction bronchiectasis (arrow). CT, computed tomography; PCR, polymerase chain reaction",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272203-1-CCR3-10-e6024-g002.jpg"
}
|
009192
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Macroscopic images and lung specimens of COVID‐19 pneumonia obtained from an autopsied case. (A) Both lungs are hyperinflated and appear to be cylindrical in shape, including overinflation of the upper lobe. (B) Gross appearance of transverse sections from the left lung. The cut surfaces also show the same cylindrical image as the whole image, due to overexpansion of the upper lobe. (C) Showing exudative phase of DAD with formation of hyaline membrane along alveolar septum (arrow), and intracapillary megakaryocytes are also present within hyaline membrane and were highlighted by CD 61 immunohistochemistry (inset). (D) Showing organizing phase of DAD with Masson body‐like structure including proliferation of fibroblast‐like cells and collagen fibers and fibroblast proliferation. (E) Showing fibrotic stage of DAD with alveolar wall thickening. (F) Showing intrapulmonary microthrombus highlighted by CD 61 immunohistochemistry (inset). CD 61, cluster of differentiation 61; COVID‐19, coronavirus disease 2019; DAD, diffuse alveolar damage",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272203-3-CCR3-10-e6024-g004.jpg"
}
|
009193
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Macroscopic and histologic images of postmortem heart from patient who died with COVID‐19. (A) Afferent hypertrophy of the myocardium. (B, C) Cardiomyocyte shedding and fibrosis, highlighted by Masson trichrome immunohistochemistry. COVID‐19, coronavirus disease 2019",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272203-4-CCR3-10-e6024-g001.jpg"
}
|
009194
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "Histopathological examination of the lung tissue (endobronchial tissue biopsy) is consistent with pulmonary actinomycosis",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272206-0-CCR3-10-e6031-g001.jpg"
}
|
009195
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "CT of the chest showing peripheral soft tissue density along the posterior basal segment of the right lung",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272206-2-CCR3-10-e6031-g003.jpg"
}
|
009196
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "MRV revealing sagittal sinus thrombosis",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272208-0-CCR3-10-e6017-g002.jpg"
}
|
009197
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "CT brain showed cerebral infarction",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272208-1-CCR3-10-e6017-g001.jpg"
}
|
009198
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
|
{
"caption": "3‐D reconstructed CT scan and coronal view demonstrating the tumor extent",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_49-PMC9272209-2-CCR3-10-e6047-g001.jpg"
}
|
009199
|
hf://datasets/vector-institute/open-pmc-18m@b5bf5b815f7ed24176e14a861ca062afe8d8775d/data_00028.tar
|
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