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Jun 6

TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks

Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope binding specificity. Scarcity of data and a large sequence space make this task challenging, and to date only models limited to a small set of epitopes have achieved good performance. Here, we establish a k-nearest-neighbor (K-NN) classifier as a strong baseline and then propose TITAN (Tcr epITope bimodal Attention Networks), a bimodal neural network that explicitly encodes both TCR sequences and epitopes to enable the independent study of generalization capabilities to unseen TCRs and/or epitopes. Results: By encoding epitopes at the atomic level with SMILES sequences, we leverage transfer learning and data augmentation to enrich the input data space and boost performance. TITAN achieves high performance in the prediction of specificity of unseen TCRs (ROC-AUC 0.87 in 10-fold CV) and surpasses the results of the current state-of-the-art (ImRex) by a large margin. Notably, our Levenshtein-distance-based K-NN classifier also exhibits competitive performance on unseen TCRs. While the generalization to unseen epitopes remains challenging, we report two major breakthroughs. First, by dissecting the attention heatmaps, we demonstrate that the sparsity of available epitope data favors an implicit treatment of epitopes as classes. This may be a general problem that limits unseen epitope performance for sufficiently complex models. Second, we show that TITAN nevertheless exhibits significantly improved performance on unseen epitopes and is capable of focusing attention on chemically meaningful molecular structures.

Performance Limits of Network Densification

Network densification is a promising cellular deployment technique that leverages spatial reuse to enhance coverage and throughput. Recent work has identified that at some point ultra-densification will no longer be able to deliver significant throughput gains. In this paper, we provide a unified treatment of the performance limits of network densification. We develop a general framework, which incorporates multi-slope pathloss and the entire space of shadowing and small scale fading distributions, under strongest cell association in a Poisson field of interferers. First, our results show that there are three scaling regimes for the downlink signal-to-interference-plus-noise ratio (SINR), coverage probability, and average per-user rate. Specifically, depending on the near-field pathloss and the fading distribution, the user performance of 5G ultra dense networks (UDNs) would either monotonically increase, saturate, or decay with increasing network density. Second, we show that network performance in terms of coverage density and area spectral efficiency can scale with the network density better than the user performance does. Furthermore, we provide ordering results for both coverage and average rate as a means to qualitatively compare different transmission techniques that may exhibit the same performance scaling. Our results, which are verified by simulations, provide succinct insights and valuable design guidelines for the deployment of 5G UDNs.

A Homogeneous Graph Neural Network for Precoding and Power Allocation in Scalable Wireless Networks

Deep learning is widely used in wireless communications but struggles with fixed neural network sizes, which limit their adaptability in environments where the number of users and antennas varies. To overcome this, this paper introduced a generalization strategy for precoding and power allocation in scalable wireless networks. Initially, we employ an innovative approach to abstract the wireless network into a homogeneous graph. This primarily focuses on bypassing the heterogeneous features between transmitter (TX) and user entities to construct a virtual homogeneous graph serving optimization objectives, thereby enabling all nodes in the virtual graph to share the same neural network. This "TX entity" is known as a base station (BS) in cellular networks and an access point (AP) in cell-free networks. Subsequently, we design a universal graph neural network, termed the information carrying graph neural network (ICGNN), to capture and integrate information from this graph, maintaining permutation invariance. Lastly, using ICGNN as the core algorithm, we tailor the neural network's input and output for specific problem requirements and validate its performance in two scenarios: 1) in cellular networks, we develop a matrix-inverse-free multi-user multi-input multi-output (MU-MIMO) precoding scheme using the conjugate gradient (CG) method, adaptable to varying user and antenna numbers; 2) in a cell-free network, facing dynamic variations in the number of users served by APs, the number of APs serving each user, and the number of antennas per AP, we propose a universal power allocation scheme. Simulations demonstrate that the proposed approach not only significantly reduces computational complexity but also achieves, and potentially exceeds, the spectral efficiency (SE) of conventional algorithms.

Federated Learning over 5G, WiFi, and Ethernet: Measurements and Evaluation

Federated Learning (FL) deployments using IoT devices is an area that is poised to significantly benefit from advances in NextG wireless. In this paper, we deploy a FL application using a 5G-NR Standalone (SA) testbed with open-source and Commercial Off-the-Shelf (COTS) components. The 5G testbed architecture consists of a network of resource-constrained edge devices, namely Raspberry Pi's, and a central server equipped with a Software Defined Radio (SDR) and running O-RAN software. Our testbed allows edge devices to communicate with the server using WiFi and Ethernet, instead of 5G. FL is deployed using the Flower FL framework, for which we developed a comprehensive instrumentation tool to collect and analyze diverse communications and machine learning performance metrics including: model aggregation time, downlink transmission time, training time, and uplink transmission time. Leveraging these measurements, we perform a comparative analysis of the FL application across three network interfaces: 5G, WiFi, and Ethernet. Our experimental results suggest that, on 5G, the uplink model transfer time is a significant factor in convergence time of FL. In particular, we find that the 5G uplink contributes to roughly 23% of the duration of one average communication round when using all edge devices in our testbed. When comparing the uplink time of the 5G testbed, we find that it is 33.3x higher than Ethernet and 17.8x higher than WiFi. Our results also suggest that 5G exacerbates the well-known straggler effect. For reproducibility, we have open-sourced our FL application, instrumentation tools, and testbed configuration.

Personalized Resource Allocation in Wireless Networks: An AI-Enabled and Big Data-Driven Multi-Objective Optimization

The design and optimization of wireless networks have mostly been based on strong mathematical and theoretical modeling. Nonetheless, as novel applications emerge in the era of 5G and beyond, unprecedented levels of complexity will be encountered in the design and optimization of the network. As a result, the use of Artificial Intelligence (AI) is envisioned for wireless network design and optimization due to the flexibility and adaptability it offers in solving extremely complex problems in real-time. One of the main future applications of AI is enabling user-level personalization for numerous use cases. AI will revolutionize the way we interact with computers in which computers will be able to sense commands and emotions from humans in a non-intrusive manner, making the entire process transparent to users. By leveraging this capability, and accelerated by the advances in computing technologies, wireless networks can be redesigned to enable the personalization of network services to the user level in real-time. While current wireless networks are being optimized to achieve a predefined set of quality requirements, the personalization technology advocated in this article is supported by an intelligent big data-driven layer designed to micro-manage the scarce network resources. This layer provides the intelligence required to decide the necessary service quality that achieves the target satisfaction level for each user. Due to its dynamic and flexible design, personalized networks are expected to achieve unprecedented improvements in optimizing two contradicting objectives in wireless networks: saving resources and improving user satisfaction levels.

Searching for MobileNetV3

We present the next generation of MobileNets based on a combination of complementary search techniques as well as a novel architecture design. MobileNetV3 is tuned to mobile phone CPUs through a combination of hardware-aware network architecture search (NAS) complemented by the NetAdapt algorithm and then subsequently improved through novel architecture advances. This paper starts the exploration of how automated search algorithms and network design can work together to harness complementary approaches improving the overall state of the art. Through this process we create two new MobileNet models for release: MobileNetV3-Large and MobileNetV3-Small which are targeted for high and low resource use cases. These models are then adapted and applied to the tasks of object detection and semantic segmentation. For the task of semantic segmentation (or any dense pixel prediction), we propose a new efficient segmentation decoder Lite Reduced Atrous Spatial Pyramid Pooling (LR-ASPP). We achieve new state of the art results for mobile classification, detection and segmentation. MobileNetV3-Large is 3.2\% more accurate on ImageNet classification while reducing latency by 15\% compared to MobileNetV2. MobileNetV3-Small is 4.6\% more accurate while reducing latency by 5\% compared to MobileNetV2. MobileNetV3-Large detection is 25\% faster at roughly the same accuracy as MobileNetV2 on COCO detection. MobileNetV3-Large LR-ASPP is 30\% faster than MobileNetV2 R-ASPP at similar accuracy for Cityscapes segmentation.

Wireless Multi-Agent Generative AI: From Connected Intelligence to Collective Intelligence

The convergence of generative large language models (LLMs), edge networks, and multi-agent systems represents a groundbreaking synergy that holds immense promise for future wireless generations, harnessing the power of collective intelligence and paving the way for self-governed networks where intelligent decision-making happens right at the edge. This article puts the stepping-stone for incorporating multi-agent generative artificial intelligence (AI) in wireless networks, and sets the scene for realizing on-device LLMs, where multi-agent LLMs are collaboratively planning and solving tasks to achieve a number of network goals. We further investigate the profound limitations of cloud-based LLMs, and explore multi-agent LLMs from a game theoretic perspective, where agents collaboratively solve tasks in competitive environments. Moreover, we establish the underpinnings for the architecture design of wireless multi-agent generative AI systems at the network level and the agent level, and we identify the wireless technologies that are envisioned to play a key role in enabling on-device LLM. To demonstrate the promising potentials of wireless multi-agent generative AI networks, we highlight the benefits that can be achieved when implementing wireless generative agents in intent-based networking, and we provide a case study to showcase how on-device LLMs can contribute to solving network intents in a collaborative fashion. We finally shed lights on potential challenges and sketch a research roadmap towards realizing the vision of wireless collective intelligence.

Big-data-driven and AI-based framework to enable personalization in wireless networks

Current communication networks use design methodologies that prevent the realization of maximum network efficiency. In the first place, while users' perception of satisfactory service diverges widely, current networks are designed to be a "universal fit," where they are generally over-engineered to deliver services appealing to all types of users. Also, current networks lack user-level data cognitive intelligence that would enable fast personalized network decisions and actions through automation. Thus, in this article, we propose the utilization of AI, big data analytics, and real-time non-intrusive user feedback in order to enable the personalization of wireless networks. Based on each user's actual QoS requirements and context, a multi-objective formulation enables the network to micro-manage and optimize the provided QoS and user satisfaction levels simultaneously. Moreover, in order to enable user feedback tracking and measurement, we propose a user satisfaction model based on the zone of tolerance concept. Furthermore, we propose a big-data-driven and AI-based personalization framework to integrate personalization into wireless networks. Finally, we implement a personalized network prototype to demonstrate the proposed personalization concept and its potential benefits through a case study. The case study shows how personalization can be realized to enable the efficient optimization of network resources such that certain requirement levels of user satisfaction and revenue in the form of saved resources are achieved.

Random Spatial Networks: Small Worlds without Clustering, Traveling Waves, and Hop-and-Spread Disease Dynamics

Random network models play a prominent role in modeling, analyzing and understanding complex phenomena on real-life networks. However, a key property of networks is often neglected: many real-world networks exhibit spatial structure, the tendency of a node to select neighbors with a probability depending on physical distance. Here, we introduce a class of random spatial networks (RSNs) which generalizes many existing random network models but adds spatial structure. In these networks, nodes are placed randomly in space and joined in edges with a probability depending on their distance and their individual expected degrees, in a manner that crucially remains analytically tractable. We use this network class to propose a new generalization of small-world networks, where the average shortest path lengths in the graph are small, as in classical Watts-Strogatz small-world networks, but with close spatial proximity of nodes that are neighbors in the network playing the role of large clustering. Small-world effects are demonstrated on these spatial small-world networks without clustering. We are able to derive partial integro-differential equations governing susceptible-infectious-recovered disease spreading through an RSN, and we demonstrate the existence of traveling wave solutions. If the distance kernel governing edge placement decays slower than exponential, the population-scale dynamics are dominated by long-range hops followed by local spread of traveling waves. This provides a theoretical modeling framework for recent observations of how epidemics like Ebola evolve in modern connected societies, with long-range connections seeding new focal points from which the epidemic locally spreads in a wavelike manner.

Efficient Telecom Specific LLM: TSLAM-Mini with QLoRA and Digital Twin Data

General-purpose large language models (LLMs), despite their broad capabilities accrued from open-world data, frequently exhibit suboptimal performance when confronted with the nuanced and specialized demands inherent in real-time telecommunications applications. This investigation addresses this critical limitation through the meticulous fine-tuning of TSLAM-Mini developed by NetoAI, a compact (3.8-billion parameter) causal language model architecturally derived from Phi-4 Mini Instruct 4B. The fine-tuning regimen leverages a bespoke dataset comprising 100,000 samples, strategically engineered to address 20 pivotal telecommunications use-cases, encompassing domains such as Network Fundamentals, IP Routing, MPLS, Network Security, Automation, OSS/BSS, RAN, Mobile Core, Satellite Communications, and Ethical AI. This dataset was curated utilizing NetoAI's DigiTwin platform, enriched with granular insights from venerated network Subject Matter Experts (SMEs) and authoritative RFC documents, thereby capturing high-fidelity representations of real-world network dynamics through simulations inspired by digital twin paradigms. Employing Quantized Low-Rank Adaptation (QLoRA), a state-of-the-art Parameter Efficient Fine-Tuning (PEFT) technique, we achieved substantial training efficiency and enabled prospective deployment on resource-constrained hardware. A novel evaluation framework, predicated on a high-capacity LLM (Qwen3-235B-A22B) functioning as an automated adjudicator, was instituted to rigorously assess instruction-following fidelity and response quality across the specified telecom use-cases. Empirical results unequivocally demonstrate TSLAM-Mini's superior aptitude in telecom-centric applications, underscoring the profound efficacy of domain-specific datasets and PEFT methodologies for advancing intelligent network management.

OmniCellTOSG: The First Cell Text-Omic Signaling Graphs Dataset for Joint LLM and GNN Modeling

Complex cell signaling systems -- governed by varying protein abundances and interactions -- generate diverse cell types across organs. These systems evolve under influences such as age, sex, diet, environmental exposures, and diseases, making them challenging to decode given the involvement of tens of thousands of genes and proteins. Recently, hundreds of millions of single-cell omics data have provided a robust foundation for understanding these signaling networks within various cell subpopulations and conditions. Inspired by the success of large foundation models (for example, large language models and large vision models) pre-trained on massive datasets, we introduce OmniCellTOSG, the first dataset of cell text-omic signaling graphs (TOSGs). Each TOSG represents the signaling network of an individual or meta-cell and is labeled with information such as organ, disease, sex, age, and cell subtype. OmniCellTOSG offers two key contributions. First, it introduces a novel graph model that integrates human-readable annotations -- such as biological functions, cellular locations, signaling pathways, related diseases, and drugs -- with quantitative gene and protein abundance data, enabling graph reasoning to decode cell signaling. This approach calls for new joint models combining large language models and graph neural networks. Second, the dataset is built from single-cell RNA sequencing data of approximately 120 million cells from diverse tissues and conditions (healthy and diseased) and is fully compatible with PyTorch. This facilitates the development of innovative cell signaling models that could transform research in life sciences, healthcare, and precision medicine. The OmniCellTOSG dataset is continuously expanding and will be updated regularly. The dataset and code are available at https://github.com/FuhaiLiAiLab/OmniCellTOSG.

Secure and Privacy-Preserving Authentication Protocols for Wireless Mesh Networks

Wireless mesh networks (WMNs) have emerged as a promising concept to meet the challenges in next-generation wireless networks such as providing flexible, adaptive, and reconfigurable architecture while offering cost-effective solutions to service providers. As WMNs become an increasingly popular replacement technology for last-mile connectivity to the home networking, community and neighborhood networking, it is imperative to design efficient and secure communication protocols for these networks. However, several vulnerabilities exist in currently existing protocols for WMNs. These security loopholes can be exploited by potential attackers to launch attack on WMNs. The absence of a central point of administration makes securing WMNs even more challenging. The broadcast nature of transmission and the dependency on the intermediate nodes for multi-hop communications lead to several security vulnerabilities in WMNs. The attacks can be external as well as internal in nature. External attacks are launched by intruders who are not authorized users of the network. For example, an intruding node may eavesdrop on the packets and replay those packets at a later point of time to gain access to the network resources. On the other hand, the internal attacks are launched by the nodes that are part of the WMN. On example of such attack is an intermediate node dropping packets which it was supposed to forward. This chapter presents a comprehensive discussion on the current authentication and privacy protection schemes for WMN. In addition, it proposes a novel security protocol for node authentication and message confidentiality and an anonymization scheme for privacy protection of users in WMNs.

Understanding Telecom Language Through Large Language Models

The recent progress of artificial intelligence (AI) opens up new frontiers in the possibility of automating many tasks involved in Telecom networks design, implementation, and deployment. This has been further pushed forward with the evolution of generative artificial intelligence (AI), including the emergence of large language models (LLMs), which is believed to be the cornerstone toward realizing self-governed, interactive AI agents. Motivated by this, in this paper, we aim to adapt the paradigm of LLMs to the Telecom domain. In particular, we fine-tune several LLMs including BERT, distilled BERT, RoBERTa and GPT-2, to the Telecom domain languages, and demonstrate a use case for identifying the 3rd Generation Partnership Project (3GPP) standard working groups. We consider training the selected models on 3GPP technical documents (Tdoc) pertinent to years 2009-2019 and predict the Tdoc categories in years 2020-2023. The results demonstrate that fine-tuning BERT and RoBERTa model achieves 84.6% accuracy, while GPT-2 model achieves 83% in identifying 3GPP working groups. The distilled BERT model with around 50% less parameters achieves similar performance as others. This corroborates that fine-tuning pretrained LLM can effectively identify the categories of Telecom language. The developed framework shows a stepping stone towards realizing intent-driven and self-evolving wireless networks from Telecom languages, and paves the way for the implementation of generative AI in the Telecom domain.

A Survey on Security and Privacy Protocols for Cognitive Wireless Sensor Networks

Wireless sensor networks have emerged as an important and new area in wireless and mobile computing research because of their numerous potential applications that range from indoor deployment scenarios in home and office to outdoor deployment in adversary's territory in tactical battleground. Since in many WSN applications, lives and livelihoods may depend on the timeliness and correctness of sensor data obtained from dispersed sensor nodes, these networks must be secured to prevent any possible attacks that may be launched on them. Security is, therefore, an important issue in WSNs. However, this issue becomes even more critical in cognitive wireless sensor networks, a type of WSN in which the sensor nodes have the capabilities of changing their transmission and reception parameters according to the radio environment under which they operate in order to achieve reliable and efficient communication and optimum utilization of the network resources. This survey paper presents a comprehensive discussion on various security issues in CWSNs by identifying numerous security threats in these networks and defense mechanisms to counter these vulnerabilities. Various types of attacks on CWSNs are categorized under different classes based on their natures and tragets, and corresponding to each attack class, appropriate security mechanisms are presented. The paper also identifies some open problems in this emerging area of wireless networking.

Gotta Detect 'Em All: Fake Base Station and Multi-Step Attack Detection in Cellular Networks

Fake base stations (FBSes) pose a significant security threat by impersonating legitimate base stations (BSes). Though efforts have been made to defeat this threat, up to this day, the presence of FBSes and the multi-step attacks (MSAs) stemming from them can lead to unauthorized surveillance, interception of sensitive information, and disruption of network services. Therefore, detecting these malicious entities is crucial to ensure the security and reliability of cellular networks. Traditional detection methods often rely on additional hardware, rules, signal scanning, changing protocol specifications, or cryptographic mechanisms that have limitations and incur huge infrastructure costs. In this paper, we develop FBSDetector-an effective and efficient detection solution that can reliably detect FBSes and MSAs from layer-3 network traces using machine learning (ML) at the user equipment (UE) side. To develop FBSDetector, we create FBSAD and MSAD, the first-ever high-quality and large-scale datasets incorporating instances of FBSes and 21 MSAs. These datasets capture the network traces in different real-world cellular network scenarios (including mobility and different attacker capabilities) incorporating legitimate BSes and FBSes. Our novel ML framework, specifically designed to detect FBSes in a multi-level approach for packet classification using stateful LSTM with attention and trace level classification and MSAs using graph learning, can effectively detect FBSes with an accuracy of 96% and a false positive rate of 2.96%, and recognize MSAs with an accuracy of 86% and a false positive rate of 3.28%. We deploy FBSDetector as a real-world solution to protect end-users through a mobile app and validate it in real-world environments. Compared to the existing heuristic-based solutions that fail to detect FBSes, FBSDetector can detect FBSes in the wild in real-time.

Multi-Agent Reinforcement Learning for Offloading Cellular Communications with Cooperating UAVs

Effective solutions for intelligent data collection in terrestrial cellular networks are crucial, especially in the context of Internet of Things applications. The limited spectrum and coverage area of terrestrial base stations pose challenges in meeting the escalating data rate demands of network users. Unmanned aerial vehicles, known for their high agility, mobility, and flexibility, present an alternative means to offload data traffic from terrestrial BSs, serving as additional access points. This paper introduces a novel approach to efficiently maximize the utilization of multiple UAVs for data traffic offloading from terrestrial BSs. Specifically, the focus is on maximizing user association with UAVs by jointly optimizing UAV trajectories and users association indicators under quality of service constraints. Since, the formulated UAVs control problem is nonconvex and combinatorial, this study leverages the multi agent reinforcement learning framework. In this framework, each UAV acts as an independent agent, aiming to maintain inter UAV cooperative behavior. The proposed approach utilizes the finite state Markov decision process to account for UAVs velocity constraints and the relationship between their trajectories and state space. A low complexity distributed state action reward state action algorithm is presented to determine UAVs optimal sequential decision making policies over training episodes. The extensive simulation results validate the proposed analysis and offer valuable insights into the optimal UAV trajectories. The derived trajectories demonstrate superior average UAV association performance compared to benchmark techniques such as Q learning and particle swarm optimization.

Outdoor-to-Indoor 28 GHz Wireless Measurements in Manhattan: Path Loss, Environmental Effects, and 90% Coverage

Outdoor-to-indoor (OtI) signal propagation further challenges the already tight link budgets at millimeter-wave (mmWave). To gain insight into OtI mmWave scenarios at 28 GHz, we conducted an extensive measurement campaign consisting of over 2,200 link measurements. In total, 43 OtI scenarios were measured in West Harlem, New York City, covering seven highly diverse buildings. The measured OtI path gain can vary by up to 40 dB for a given link distance, and the empirical path gain model for all data shows an average of 30 dB excess loss over free space at distances beyond 50 m, with an RMS fitting error of 11.7 dB. The type of glass is found to be the single dominant feature for OtI loss, with 20 dB observed difference between empirical path gain models for scenarios with low-loss and high-loss glass. The presence of scaffolding, tree foliage, or elevated subway tracks, as well as difference in floor height are each found to have an impact between 5-10 dB. We show that for urban buildings with high-loss glass, OtI coverage can support 500 Mbps for 90% of indoor user equipment (UEs) with a base station (BS) antenna placed up to 49 m away. For buildings with low-loss glass, such as our case study covering multiple classrooms of a public school, data rates over 2.5/1.2 Gbps are possible from a BS 68/175 m away from the school building, when a line-of-sight path is available. We expect these results to be useful for the deployment of mmWave networks in dense urban environments as well as the development of relevant scheduling and beam management algorithms.

On-device Online Learning and Semantic Management of TinyML Systems

Recent advances in Tiny Machine Learning (TinyML) empower low-footprint embedded devices for real-time on-device Machine Learning. While many acknowledge the potential benefits of TinyML, its practical implementation presents unique challenges. This study aims to bridge the gap between prototyping single TinyML models and developing reliable TinyML systems in production: (1) Embedded devices operate in dynamically changing conditions. Existing TinyML solutions primarily focus on inference, with models trained offline on powerful machines and deployed as static objects. However, static models may underperform in the real world due to evolving input data distributions. We propose online learning to enable training on constrained devices, adapting local models towards the latest field conditions. (2) Nevertheless, current on-device learning methods struggle with heterogeneous deployment conditions and the scarcity of labeled data when applied across numerous devices. We introduce federated meta-learning incorporating online learning to enhance model generalization, facilitating rapid learning. This approach ensures optimal performance among distributed devices by knowledge sharing. (3) Moreover, TinyML's pivotal advantage is widespread adoption. Embedded devices and TinyML models prioritize extreme efficiency, leading to diverse characteristics ranging from memory and sensors to model architectures. Given their diversity and non-standardized representations, managing these resources becomes challenging as TinyML systems scale up. We present semantic management for the joint management of models and devices at scale. We demonstrate our methods through a basic regression example and then assess them in three real-world TinyML applications: handwritten character image classification, keyword audio classification, and smart building presence detection, confirming our approaches' effectiveness.

Geo2SigMap: High-Fidelity RF Signal Mapping Using Geographic Databases

Radio frequency (RF) signal mapping, which is the process of analyzing and predicting the RF signal strength and distribution across specific areas, is crucial for cellular network planning and deployment. Traditional approaches to RF signal mapping rely on statistical models constructed based on measurement data, which offer low complexity but often lack accuracy, or ray tracing tools, which provide enhanced precision for the target area but suffer from increased computational complexity. Recently, machine learning (ML) has emerged as a data-driven method for modeling RF signal propagation, which leverages models trained on synthetic datasets to perform RF signal mapping in "unseen" areas. In this paper, we present Geo2SigMap, an ML-based framework for efficient and high-fidelity RF signal mapping using geographic databases. First, we develop an automated framework that seamlessly integrates three open-source tools: OpenStreetMap (geographic databases), Blender (computer graphics), and Sionna (ray tracing), enabling the efficient generation of large-scale 3D building maps and ray tracing models. Second, we propose a cascaded U-Net model, which is pre-trained on synthetic datasets and employed to generate detailed RF signal maps, leveraging environmental information and sparse measurement data. Finally, we evaluate the performance of Geo2SigMap via a real-world measurement campaign, where three types of user equipment (UE) collect over 45,000 data points related to cellular information from six LTE cells operating in the citizens broadband radio service (CBRS) band. Our results show that Geo2SigMap achieves an average root-mean-square-error (RMSE) of 6.04 dB for predicting the reference signal received power (RSRP) at the UE, representing an average RMSE improvement of 3.59 dB compared to existing methods.

GRNFormer: A Biologically-Guided Framework for Integrating Gene Regulatory Networks into RNA Foundation Models

Foundation models for single-cell RNA sequencing (scRNA-seq) have shown promising capabilities in capturing gene expression patterns. However, current approaches face critical limitations: they ignore biological prior knowledge encoded in gene regulatory relationships and fail to leverage multi-omics signals that could provide complementary regulatory insights. In this paper, we propose GRNFormer, a new framework that systematically integrates multi-scale Gene Regulatory Networks (GRNs) inferred from multi-omics data into RNA foundation model training. Our framework introduces two key innovations. First, we introduce a pipeline for constructing hierarchical GRNs that capture regulatory relationships at both cell-type-specific and cell-specific resolutions. Second, we design a structure-aware integration framework that addresses the information asymmetry in GRNs through two technical advances: (1) A graph topological adapter using multi-head cross-attention to weight regulatory relationships dynamically, and (2) a novel edge perturbation strategy that perturb GRNs with biologically-informed co-expression links to augment graph neural network training. Comprehensive experiments have been conducted on three representative downstream tasks across multiple model architectures to demonstrate the effectiveness of GRNFormer. It achieves consistent improvements over state-of-the-art (SoTA) baselines: 3.6% increase in drug response prediction correlation, 9.6% improvement in single-cell drug classification AUC, and 1.1% average gain in gene perturbation prediction accuracy.

Spatial Channel State Information Prediction with Generative AI: Towards Holographic Communication and Digital Radio Twin

As 5G technology becomes increasingly established, the anticipation for 6G is growing, which promises to deliver faster and more reliable wireless connections via cutting-edge radio technologies. However, efficient management method of the large-scale antenna arrays deployed by those radio technologies is crucial. Traditional management methods are mainly reactive, usually based on feedback from users to adapt to the dynamic wireless channel. However, a more promising approach lies in the prediction of spatial channel state information (spatial-CSI), which is an all-inclusive channel characterization and consists of all the feasible line-of-sight (LoS) and non-line-of-sight (NLoS) paths between the transmitter (Tx) and receiver (Rx), with the three-dimension (3D) trajectory, attenuation, phase shift, delay, and polarization of each path. Advances in hardware and neural networks make it possible to predict such spatial-CSI using precise environmental information, and further look into the possibility of holographic communication, which implies complete control over every aspect of the radio waves emitted. Based on the integration of holographic communication and digital twin, we proposed a new framework, digital radio twin, which takes advantages from both the digital world and deterministic control over radio waves, supporting a wide range of high-level applications. As a preliminary attempt towards this visionary direction, in this paper, we explore the use of generative artificial intelligence (AI) to pinpoint the valid paths in a given environment, demonstrating promising results, and highlighting the potential of this approach in driving forward the evolution of 6G wireless communication technologies.

A Hardware-Aware System for Accelerating Deep Neural Network Optimization

Recent advances in Neural Architecture Search (NAS) which extract specialized hardware-aware configurations (a.k.a. "sub-networks") from a hardware-agnostic "super-network" have become increasingly popular. While considerable effort has been employed towards improving the first stage, namely, the training of the super-network, the search for derivative high-performing sub-networks is still largely under-explored. For example, some recent network morphism techniques allow a super-network to be trained once and then have hardware-specific networks extracted from it as needed. These methods decouple the super-network training from the sub-network search and thus decrease the computational burden of specializing to different hardware platforms. We propose a comprehensive system that automatically and efficiently finds sub-networks from a pre-trained super-network that are optimized to different performance metrics and hardware configurations. By combining novel search tactics and algorithms with intelligent use of predictors, we significantly decrease the time needed to find optimal sub-networks from a given super-network. Further, our approach does not require the super-network to be refined for the target task a priori, thus allowing it to interface with any super-network. We demonstrate through extensive experiments that our system works seamlessly with existing state-of-the-art super-network training methods in multiple domains. Moreover, we show how novel search tactics paired with evolutionary algorithms can accelerate the search process for ResNet50, MobileNetV3 and Transformer while maintaining objective space Pareto front diversity and demonstrate an 8x faster search result than the state-of-the-art Bayesian optimization WeakNAS approach.

Single-Cell Omics Arena: A Benchmark Study for Large Language Models on Cell Type Annotation Using Single-Cell Data

Over the past decade, the revolution in single-cell sequencing has enabled the simultaneous molecular profiling of various modalities across thousands of individual cells, allowing scientists to investigate the diverse functions of complex tissues and uncover underlying disease mechanisms. Among all the analytical steps, assigning individual cells to specific types is fundamental for understanding cellular heterogeneity. However, this process is usually labor-intensive and requires extensive expert knowledge. Recent advances in large language models (LLMs) have demonstrated their ability to efficiently process and synthesize vast corpora of text to automatically extract essential biological knowledge, such as marker genes, potentially promoting more efficient and automated cell type annotations. To thoroughly evaluate the capability of modern instruction-tuned LLMs in automating the cell type identification process, we introduce SOAR, a comprehensive benchmarking study of LLMs for cell type annotation tasks in single-cell genomics. Specifically, we assess the performance of 8 instruction-tuned LLMs across 11 datasets, spanning multiple cell types and species. Our study explores the potential of LLMs to accurately classify and annotate cell types in single-cell RNA sequencing (scRNA-seq) data, while extending their application to multiomics data through cross-modality translation. Additionally, we evaluate the effectiveness of chain-of-thought (CoT) prompting techniques in generating detailed biological insights during the annotation process. The results demonstrate that LLMs can provide robust interpretations of single-cell data without requiring additional fine-tuning, advancing the automation of cell type annotation in genomics research.

The TYC Dataset for Understanding Instance-Level Semantics and Motions of Cells in Microstructures

Segmenting cells and tracking their motion over time is a common task in biomedical applications. However, predicting accurate instance-wise segmentation and cell motions from microscopy imagery remains a challenging task. Using microstructured environments for analyzing single cells in a constant flow of media adds additional complexity. While large-scale labeled microscopy datasets are available, we are not aware of any large-scale dataset, including both cells and microstructures. In this paper, we introduce the trapped yeast cell (TYC) dataset, a novel dataset for understanding instance-level semantics and motions of cells in microstructures. We release 105 dense annotated high-resolution brightfield microscopy images, including about 19k instance masks. We also release 261 curated video clips composed of 1293 high-resolution microscopy images to facilitate unsupervised understanding of cell motions and morphology. TYC offers ten times more instance annotations than the previously largest dataset, including cells and microstructures. Our effort also exceeds previous attempts in terms of microstructure variability, resolution, complexity, and capturing device (microscopy) variability. We facilitate a unified comparison on our novel dataset by introducing a standardized evaluation strategy. TYC and evaluation code are publicly available under CC BY 4.0 license.

TEDDY: A Family Of Foundation Models For Understanding Single Cell Biology

Understanding the biological mechanism of disease is critical for medicine, and in particular drug discovery. AI-powered analysis of genome-scale biological data hold great potential in this regard. The increasing availability of single-cell RNA sequencing data has enabled the development of large foundation models for disease biology. However, existing foundation models either do not improve or only modestly improve over task-specific models in downstream applications. Here, we explored two avenues for improving the state-of-the-art. First, we scaled the pre-training dataset to 116 million cells, which is larger than those used by previous models. Second, we leveraged the availability of large-scale biological annotations as a form of supervision during pre-training. We trained the TEDDY family of models comprising six transformer-based state-of-the-art single-cell foundation models with 70 million, 160 million, and 400 million parameters. We vetted our models on two downstream evaluation tasks -- identifying the underlying disease state of held-out donors not seen during training and distinguishing healthy cells from diseased ones for disease conditions and donors not seen during training. Scaling experiments showed that performance improved predictably with both data volume and parameter count. Our models showed substantial improvement over existing work on the first task and more muted improvements on the second.

RADIANCE: Radio-Frequency Adversarial Deep-learning Inference for Automated Network Coverage Estimation

Radio-frequency coverage maps (RF maps) are extensively utilized in wireless networks for capacity planning, placement of access points and base stations, localization, and coverage estimation. Conducting site surveys to obtain RF maps is labor-intensive and sometimes not feasible. In this paper, we propose radio-frequency adversarial deep-learning inference for automated network coverage estimation (RADIANCE), a generative adversarial network (GAN) based approach for synthesizing RF maps in indoor scenarios. RADIANCE utilizes a semantic map, a high-level representation of the indoor environment to encode spatial relationships and attributes of objects within the environment and guide the RF map generation process. We introduce a new gradient-based loss function that computes the magnitude and direction of change in received signal strength (RSS) values from a point within the environment. RADIANCE incorporates this loss function along with the antenna pattern to capture signal propagation within a given indoor configuration and generate new patterns under new configuration, antenna (beam) pattern, and center frequency. Extensive simulations are conducted to compare RADIANCE with ray-tracing simulations of RF maps. Our results show that RADIANCE achieves a mean average error (MAE) of 0.09, root-mean-squared error (RMSE) of 0.29, peak signal-to-noise ratio (PSNR) of 10.78, and multi-scale structural similarity index (MS-SSIM) of 0.80.

Exploring the Impact of Disrupted Peer-to-Peer Communications on Fully Decentralized Learning in Disaster Scenarios

Fully decentralized learning enables the distribution of learning resources and decision-making capabilities across multiple user devices or nodes, and is rapidly gaining popularity due to its privacy-preserving and decentralized nature. Importantly, this crowdsourcing of the learning process allows the system to continue functioning even if some nodes are affected or disconnected. In a disaster scenario, communication infrastructure and centralized systems may be disrupted or completely unavailable, hindering the possibility of carrying out standard centralized learning tasks in these settings. Thus, fully decentralized learning can help in this case. However, transitioning from centralized to peer-to-peer communications introduces a dependency between the learning process and the topology of the communication graph among nodes. In a disaster scenario, even peer-to-peer communications are susceptible to abrupt changes, such as devices running out of battery or getting disconnected from others due to their position. In this study, we investigate the effects of various disruptions to peer-to-peer communications on decentralized learning in a disaster setting. We examine the resilience of a decentralized learning process when a subset of devices drop from the process abruptly. To this end, we analyze the difference between losing devices holding data, i.e., potential knowledge, vs. devices contributing only to the graph connectivity, i.e., with no data. Our findings on a Barabasi-Albert graph topology, where training data is distributed across nodes in an IID fashion, indicate that the accuracy of the learning process is more affected by a loss of connectivity than by a loss of data. Nevertheless, the network remains relatively robust, and the learning process can achieve a good level of accuracy.

An Anonymous Authentication and Communication Protocol for Wireless Mesh Networks

Wireless mesh networks (WMNs) have emerged as a key technology for next generation wireless broadband networks showing rapid progress and inspiring numerous compelling applications. A WMN comprises of a set of mesh routers (MRs) and mesh clients (MCs), where MRs are connected to the Internet backbone through the Internet gateways (IGWs). The MCs are wireless devices and communicate among themselves over possibly multi-hop paths with or without the involvement of MRs. User privacy and security have been primary concerns in WMNs due to their peer-to-peer network topology, shared wireless medium, stringent resource constraints, and highly dynamic environment. Moreover, to support real-time applications, WMNs must also be equipped with robust, reliable and efficient communication protocols so as to minimize the end-to-end latency and packet drops. Design of a secure and efficient communication protocol for WMNs, therefore, is of paramount importance. In this paper, we propose a security and privacy protocol that provides security and user anonymity while maintaining communication efficiency in a WMN. The security protocol ensures secure authentication and encryption in access and the backbone networks. The user anonymity, authentication and data privacy is achieved by application of a protocol that is based on Rivest's ring signature scheme. Simulation results demonstrate that while the protocols have minimal storage and communication overhead, they are robust and provide high level of security and privacy to the users of the network services.

From Cities to Series: Complex Networks and Deep Learning for Improved Spatial and Temporal Analytics*

Graphs have often been used to answer questions about the interaction between real-world entities by taking advantage of their capacity to represent complex topologies. Complex networks are known to be graphs that capture such non-trivial topologies; they are able to represent human phenomena such as epidemic processes, the dynamics of populations, and the urbanization of cities. The investigation of complex networks has been extrapolated to many fields of science, with particular emphasis on computing techniques, including artificial intelligence. In such a case, the analysis of the interaction between entities of interest is transposed to the internal learning of algorithms, a paradigm whose investigation is able to expand the state of the art in Computer Science. By exploring this paradigm, this thesis puts together complex networks and machine learning techniques to improve the understanding of the human phenomena observed in pandemics, pendular migration, and street networks. Accordingly, we contribute with: (i) a new neural network architecture capable of modeling dynamic processes observed in spatial and temporal data with applications in epidemics propagation, weather forecasting, and patient monitoring in intensive care units; (ii) a machine-learning methodology for analyzing and predicting links in the scope of human mobility between all the cities of Brazil; and, (iii) techniques for identifying inconsistencies in the urban planning of cities while tracking the most influential vertices, with applications over Brazilian and worldwide cities. We obtained results sustained by sound evidence of advances to the state of the art in artificial intelligence, rigorous formalisms, and ample experimentation. Our findings rely upon real-world applications in a range of domains, demonstrating the applicability of our methodologies.

SparseByteNN: A Novel Mobile Inference Acceleration Framework Based on Fine-Grained Group Sparsity

To address the challenge of increasing network size, researchers have developed sparse models through network pruning. However, maintaining model accuracy while achieving significant speedups on general computing devices remains an open problem. In this paper, we present a novel mobile inference acceleration framework SparseByteNN, which leverages fine-grained kernel sparsity to achieve real-time execution as well as high accuracy. Our framework consists of two parts: (a) A fine-grained kernel sparsity schema with a sparsity granularity between structured pruning and unstructured pruning. It designs multiple sparse patterns for different operators. Combined with our proposed whole network rearrangement strategy, the schema achieves a high compression rate and high precision at the same time. (b) Inference engine co-optimized with the sparse pattern. The conventional wisdom is that this reduction in theoretical FLOPs does not translate into real-world efficiency gains. We aim to correct this misconception by introducing a family of efficient sparse kernels for ARM and WebAssembly. Equipped with our efficient implementation of sparse primitives, we show that sparse versions of MobileNet-v1 outperform strong dense baselines on the efficiency-accuracy curve. Experimental results on Qualcomm 855 show that for 30% sparse MobileNet-v1, SparseByteNN achieves 1.27x speedup over the dense version and 1.29x speedup over the state-of-the-art sparse inference engine MNN with a slight accuracy drop of 0.224%. The source code of SparseByteNN will be available at https://github.com/lswzjuer/SparseByteNN

Meta Flow Matching: Integrating Vector Fields on the Wasserstein Manifold

Numerous biological and physical processes can be modeled as systems of interacting entities evolving continuously over time, e.g. the dynamics of communicating cells or physical particles. Learning the dynamics of such systems is essential for predicting the temporal evolution of populations across novel samples and unseen environments. Flow-based models allow for learning these dynamics at the population level - they model the evolution of the entire distribution of samples. However, current flow-based models are limited to a single initial population and a set of predefined conditions which describe different dynamics. We argue that multiple processes in natural sciences have to be represented as vector fields on the Wasserstein manifold of probability densities. That is, the change of the population at any moment in time depends on the population itself due to the interactions between samples. In particular, this is crucial for personalized medicine where the development of diseases and their respective treatment response depends on the microenvironment of cells specific to each patient. We propose Meta Flow Matching (MFM), a practical approach to integrating along these vector fields on the Wasserstein manifold by amortizing the flow model over the initial populations. Namely, we embed the population of samples using a Graph Neural Network (GNN) and use these embeddings to train a Flow Matching model. This gives MFM the ability to generalize over the initial distributions unlike previously proposed methods. We demonstrate the ability of MFM to improve prediction of individual treatment responses on a large scale multi-patient single-cell drug screen dataset.

Defeating Proactive Jammers Using Deep Reinforcement Learning for Resource-Constrained IoT Networks

Traditional anti-jamming techniques like spread spectrum, adaptive power/rate control, and cognitive radio, have demonstrated effectiveness in mitigating jamming attacks. However, their robustness against the growing complexity of internet-of-thing (IoT) networks and diverse jamming attacks is still limited. To address these challenges, machine learning (ML)-based techniques have emerged as promising solutions. By offering adaptive and intelligent anti-jamming capabilities, ML-based approaches can effectively adapt to dynamic attack scenarios and overcome the limitations of traditional methods. In this paper, we propose a deep reinforcement learning (DRL)-based approach that utilizes state input from realistic wireless network interface cards. We train five different variants of deep Q-network (DQN) agents to mitigate the effects of jamming with the aim of identifying the most sample-efficient, lightweight, robust, and least complex agent that is tailored for power-constrained devices. The simulation results demonstrate the effectiveness of the proposed DRL-based anti-jamming approach against proactive jammers, regardless of their jamming strategy which eliminates the need for a pattern recognition or jamming strategy detection step. Our findings present a promising solution for securing IoT networks against jamming attacks and highlights substantial opportunities for continued investigation and advancement within this field.

Neural Compression and Filtering for Edge-assisted Real-time Object Detection in Challenged Networks

The edge computing paradigm places compute-capable devices - edge servers - at the network edge to assist mobile devices in executing data analysis tasks. Intuitively, offloading compute-intense tasks to edge servers can reduce their execution time. However, poor conditions of the wireless channel connecting the mobile devices to the edge servers may degrade the overall capture-to-output delay achieved by edge offloading. Herein, we focus on edge computing supporting remote object detection by means of Deep Neural Networks (DNNs), and develop a framework to reduce the amount of data transmitted over the wireless link. The core idea we propose builds on recent approaches splitting DNNs into sections - namely head and tail models - executed by the mobile device and edge server, respectively. The wireless link, then, is used to transport the output of the last layer of the head model to the edge server, instead of the DNN input. Most prior work focuses on classification tasks and leaves the DNN structure unaltered. Herein, our focus is on DNNs for three different object detection tasks, which present a much more convoluted structure, and modify the architecture of the network to: (i) achieve in-network compression by introducing a bottleneck layer in the early layers on the head model, and (ii) prefilter pictures that do not contain objects of interest using a convolutional neural network. Results show that the proposed technique represents an effective intermediate option between local and edge computing in a parameter region where these extreme point solutions fail to provide satisfactory performance. The code and trained models are available at https://github.com/yoshitomo-matsubara/hnd-ghnd-object-detectors .

Over-The-Air Double-Threshold Deep Learner for Jamming Detection in 5G RF domain

With the evolution of 5G wireless communications, the Synchronization Signal Block (SSB) plays a critical role in the synchronization of devices and accessibility of services. However, due to the predictable nature of SSB transmission, including the Primary and Secondary Synchronization Signals (PSS and SSS), jamming attacks are critical threats. By leveraging RF domain knowledge, this work presents a novel deep learning-based technique for detecting jammers in 5G networks. Unlike the existing jamming detection algorithms that mostly rely on network parameters, we introduce a double threshold deep learning jamming detector by focusing on the SSB. The detection method is focused on RF domain features and improves the robustness of the network without requiring integration with the pre-existing network infrastructure. By integrating a preprocessing block that extracts PSS correlation and energy per null resource elements (EPNRE) characteristics, our method distinguishes between normal and jammed received signals with high precision. Additionally, by incorporation of Discrete Wavelet Transform (DWT), the efficacy of training and detection are optimized. A double threshold double Deep Neural Network (DT-DDNN) is also introduced to the architecture complemented by a deep cascade learning model to increase the sensitivity of the model to variations of signal to jamming noise ratio (SJNR). Results show that the proposed method achieves 96.4% detection rate in extra low jamming power, i.e., SJNR between 15 to 30 dB which outperforms the single threshold DNN design with 86.0% detection rate and unprocessed IQ sample DNN design with 83.2% detection rate. Ultimately, performance of DT-DDNN is validated through the analysis of real 5G signals obtained from a practical testbed, demonstrating a strong alignment with the simulation results.

Reconstructing commuters network using machine learning and urban indicators

Human mobility has a significant impact on several layers of society, from infrastructural planning and economics to the spread of diseases and crime. Representing the system as a complex network, in which nodes are assigned to regions (e.g., a city) and links indicate the flow of people between two of them, physics-inspired models have been proposed to quantify the number of people migrating from one city to the other. Despite the advances made by these models, our ability to predict the number of commuters and reconstruct mobility networks remains limited. Here, we propose an alternative approach using machine learning and 22 urban indicators to predict the flow of people and reconstruct the intercity commuters network. Our results reveal that predictions based on machine learning algorithms and urban indicators can reconstruct the commuters network with 90.4% of accuracy and describe 77.6% of the variance observed in the flow of people between cities. We also identify essential features to recover the network structure and the urban indicators mostly related to commuting patterns. As previously reported, distance plays a significant role in commuting, but other indicators, such as Gross Domestic Product (GDP) and unemployment rate, are also driven-forces for people to commute. We believe that our results shed new lights on the modeling of migration and reinforce the role of urban indicators on commuting patterns. Also, because link-prediction and network reconstruction are still open challenges in network science, our results have implications in other areas, like economics, social sciences, and biology, where node attributes can give us information about the existence of links connecting entities in the network.

RFRL Gym: A Reinforcement Learning Testbed for Cognitive Radio Applications

Radio Frequency Reinforcement Learning (RFRL) is anticipated to be a widely applicable technology in the next generation of wireless communication systems, particularly 6G and next-gen military communications. Given this, our research is focused on developing a tool to promote the development of RFRL techniques that leverage spectrum sensing. In particular, the tool was designed to address two cognitive radio applications, specifically dynamic spectrum access and jamming. In order to train and test reinforcement learning (RL) algorithms for these applications, a simulation environment is necessary to simulate the conditions that an agent will encounter within the Radio Frequency (RF) spectrum. In this paper, such an environment has been developed, herein referred to as the RFRL Gym. Through the RFRL Gym, users can design their own scenarios to model what an RL agent may encounter within the RF spectrum as well as experiment with different spectrum sensing techniques. Additionally, the RFRL Gym is a subclass of OpenAI gym, enabling the use of third-party ML/RL Libraries. We plan to open-source this codebase to enable other researchers to utilize the RFRL Gym to test their own scenarios and RL algorithms, ultimately leading to the advancement of RL research in the wireless communications domain. This paper describes in further detail the components of the Gym, results from example scenarios, and plans for future additions. Index Terms-machine learning, reinforcement learning, wireless communications, dynamic spectrum access, OpenAI gym

SAI: Solving AI Tasks with Systematic Artificial Intelligence in Communication Network

In the rapid development of artificial intelligence, solving complex AI tasks is a crucial technology in intelligent mobile networks. Despite the good performance of specialized AI models in intelligent mobile networks, they are unable to handle complicated AI tasks. To address this challenge, we propose Systematic Artificial Intelligence (SAI), which is a framework designed to solve AI tasks by leveraging Large Language Models (LLMs) and JSON-format intent-based input to connect self-designed model library and database. Specifically, we first design a multi-input component, which simultaneously integrates Large Language Models (LLMs) and JSON-format intent-based inputs to fulfill the diverse intent requirements of different users. In addition, we introduce a model library module based on model cards which employ model cards to pairwise match between different modules for model composition. Model cards contain the corresponding model's name and the required performance metrics. Then when receiving user network requirements, we execute each subtask for multiple selected model combinations and provide output based on the execution results and LLM feedback. By leveraging the language capabilities of LLMs and the abundant AI models in the model library, SAI can complete numerous complex AI tasks in the communication network, achieving impressive results in network optimization, resource allocation, and other challenging tasks.

Artificial General Intelligence (AGI)-Native Wireless Systems: A Journey Beyond 6G

Building future wireless systems that support services like digital twins (DTs) is challenging to achieve through advances to conventional technologies like meta-surfaces. While artificial intelligence (AI)-native networks promise to overcome some limitations of wireless technologies, developments still rely on AI tools like neural networks. Such tools struggle to cope with the non-trivial challenges of the network environment and the growing demands of emerging use cases. In this paper, we revisit the concept of AI-native wireless systems, equipping them with the common sense necessary to transform them into artificial general intelligence (AGI)-native systems. These systems acquire common sense by exploiting different cognitive abilities such as perception, analogy, and reasoning, that enable them to generalize and deal with unforeseen scenarios. Towards developing the components of such a system, we start by showing how the perception module can be built through abstracting real-world elements into generalizable representations. These representations are then used to create a world model, founded on principles of causality and hyper-dimensional (HD) computing, that aligns with intuitive physics and enables analogical reasoning, that define common sense. Then, we explain how methods such as integrated information theory play a role in the proposed intent-driven and objective-driven planning methods that maneuver the AGI-native network to take actions. Next, we discuss how an AGI-native network can enable use cases related to human and autonomous agents: a) analogical reasoning for next-generation DTs, b) synchronized and resilient experiences for cognitive avatars, and c) brain-level metaverse experiences like holographic teleportation. Finally, we conclude with a set of recommendations to build AGI-native systems. Ultimately, we envision this paper as a roadmap for the beyond 6G era.

Model Rubik's Cube: Twisting Resolution, Depth and Width for TinyNets

To obtain excellent deep neural architectures, a series of techniques are carefully designed in EfficientNets. The giant formula for simultaneously enlarging the resolution, depth and width provides us a Rubik's cube for neural networks. So that we can find networks with high efficiency and excellent performance by twisting the three dimensions. This paper aims to explore the twisting rules for obtaining deep neural networks with minimum model sizes and computational costs. Different from the network enlarging, we observe that resolution and depth are more important than width for tiny networks. Therefore, the original method, i.e., the compound scaling in EfficientNet is no longer suitable. To this end, we summarize a tiny formula for downsizing neural architectures through a series of smaller models derived from the EfficientNet-B0 with the FLOPs constraint. Experimental results on the ImageNet benchmark illustrate that our TinyNet performs much better than the smaller version of EfficientNets using the inversed giant formula. For instance, our TinyNet-E achieves a 59.9% Top-1 accuracy with only 24M FLOPs, which is about 1.9% higher than that of the previous best MobileNetV3 with similar computational cost. Code will be available at https://github.com/huawei-noah/ghostnet/tree/master/tinynet_pytorch, and https://gitee.com/mindspore/mindspore/tree/master/model_zoo/research/cv/tinynet.

PLM: Efficient Peripheral Language Models Hardware-Co-Designed for Ubiquitous Computing

While scaling laws have been continuously validated in large language models (LLMs) with increasing model parameters, the inherent tension between the inference demands of LLMs and the limited resources of edge devices poses a critical challenge to the development of edge intelligence. Recently, numerous small language models have emerged, aiming to distill the capabilities of LLMs into smaller footprints. However, these models often retain the fundamental architectural principles of their larger counterparts, still imposing considerable strain on the storage and bandwidth capacities of edge devices. In this paper, we introduce the PLM, a Peripheral Language Model, developed through a co-design process that jointly optimizes model architecture and edge system constraints. The PLM utilizes a Multi-head Latent Attention mechanism and employs the squared ReLU activation function to encourage sparsity, thereby reducing peak memory footprint during inference. During training, we collect and reorganize open-source datasets, implement a multi-phase training strategy, and empirically investigate the Warmup-Stable-Decay-Constant (WSDC) learning rate scheduler. Additionally, we incorporate Reinforcement Learning from Human Feedback (RLHF) by adopting the ARIES preference learning approach. Following a two-phase SFT process, this method yields performance gains of 2% in general tasks, 9% in the GSM8K task, and 11% in coding tasks. In addition to its novel architecture, evaluation results demonstrate that PLM outperforms existing small language models trained on publicly available data while maintaining the lowest number of activated parameters. Furthermore, deployment across various edge devices, including consumer-grade GPUs, mobile phones, and Raspberry Pis, validates PLM's suitability for peripheral applications. The PLM series models are publicly available at https://github.com/plm-team/PLM.

μ-Bench: A Vision-Language Benchmark for Microscopy Understanding

Recent advances in microscopy have enabled the rapid generation of terabytes of image data in cell biology and biomedical research. Vision-language models (VLMs) offer a promising solution for large-scale biological image analysis, enhancing researchers' efficiency, identifying new image biomarkers, and accelerating hypothesis generation and scientific discovery. However, there is a lack of standardized, diverse, and large-scale vision-language benchmarks to evaluate VLMs' perception and cognition capabilities in biological image understanding. To address this gap, we introduce {\mu}-Bench, an expert-curated benchmark encompassing 22 biomedical tasks across various scientific disciplines (biology, pathology), microscopy modalities (electron, fluorescence, light), scales (subcellular, cellular, tissue), and organisms in both normal and abnormal states. We evaluate state-of-the-art biomedical, pathology, and general VLMs on {\mu}-Bench and find that: i) current models struggle on all categories, even for basic tasks such as distinguishing microscopy modalities; ii) current specialist models fine-tuned on biomedical data often perform worse than generalist models; iii) fine-tuning in specific microscopy domains can cause catastrophic forgetting, eroding prior biomedical knowledge encoded in their base model. iv) weight interpolation between fine-tuned and pre-trained models offers one solution to forgetting and improves general performance across biomedical tasks. We release {\mu}-Bench under a permissive license to accelerate the research and development of microscopy foundation models.

Wireless-Enabled Asynchronous Federated Fourier Neural Network for Turbulence Prediction in Urban Air Mobility (UAM)

To meet the growing mobility needs in intra-city transportation, the concept of urban air mobility (UAM) has been proposed in which vertical takeoff and landing (VTOL) aircraft are used to provide a ride-hailing service. In UAM, aircraft can operate in designated air spaces known as corridors, that link the aerodromes. A reliable communication network between GBSs and aircraft enables UAM to adequately utilize the airspace and create a fast, efficient, and safe transportation system. In this paper, to characterize the wireless connectivity performance for UAM, a spatial model is proposed. For this setup, the distribution of the distance between an arbitrarily selected GBS and its associated aircraft and the Laplace transform of the interference experienced by the GBS are derived. Using these results, the signal-to-interference ratio (SIR)-based connectivity probability is determined to capture the connectivity performance of the UAM aircraft-to-ground communication network. Then, leveraging these connectivity results, a wireless-enabled asynchronous federated learning (AFL) framework that uses a Fourier neural network is proposed to tackle the challenging problem of turbulence prediction during UAM operations. For this AFL scheme, a staleness-aware global aggregation scheme is introduced to expedite the convergence to the optimal turbulence prediction model used by UAM aircraft. Simulation results validate the theoretical derivations for the UAM wireless connectivity. The results also demonstrate that the proposed AFL framework converges to the optimal turbulence prediction model faster than the synchronous federated learning baselines and a staleness-free AFL approach. Furthermore, the results characterize the performance of wireless connectivity and convergence of the aircraft's turbulence model under different parameter settings, offering useful UAM design guidelines.

Simplicial Closure and higher-order link prediction

Networks provide a powerful formalism for modeling complex systems by using a model of pairwise interactions. But much of the structure within these systems involves interactions that take place among more than two nodes at once; for example, communication within a group rather than person-to person, collaboration among a team rather than a pair of coauthors, or biological interaction between a set of molecules rather than just two. Such higher-order interactions are ubiquitous, but their empirical study has received limited attention, and little is known about possible organizational principles of such structures. Here we study the temporal evolution of 19 datasets with explicit accounting for higher-order interactions. We show that there is a rich variety of structure in our datasets but datasets from the same system types have consistent patterns of higher-order structure. Furthermore, we find that tie strength and edge density are competing positive indicators of higher-order organization, and these trends are consistent across interactions involving differing numbers of nodes. To systematically further the study of theories for such higher-order structures, we propose higher-order link prediction as a benchmark problem to assess models and algorithms that predict higher-order structure. We find a fundamental differences from traditional pairwise link prediction, with a greater role for local rather than long-range information in predicting the appearance of new interactions.

Are We There Yet? A Measurement Study of Efficiency for LLM Applications on Mobile Devices

Recent advancements in large language models (LLMs) have prompted interest in deploying these models on mobile devices to enable new applications without relying on cloud connectivity. However, the efficiency constraints of deploying LLMs on resource-limited devices present significant challenges. In this paper, we conduct a comprehensive measurement study to evaluate the efficiency tradeoffs between mobile-based, edge-based, and cloud-based deployments for LLM applications. We implement AutoLife-Lite, a simplified LLM-based application that analyzes smartphone sensor data to infer user location and activity contexts. Our experiments reveal that: (1) Only small-size LLMs (<4B parameters) can run successfully on powerful mobile devices, though they exhibit quality limitations compared to larger models; (2) Model compression is effective in lower the hardware requirement, but may lead to significant performance degradation; (3) The latency to run LLMs on mobile devices with meaningful output is significant (>30 seconds), while cloud services demonstrate better time efficiency (<10 seconds); (4) Edge deployments offer intermediate tradeoffs between latency and model capabilities, with different results on CPU-based and GPU-based settings. These findings provide valuable insights for system designers on the current limitations and future directions for on-device LLM applications.

Prime Collective Communications Library -- Technical Report

This report presents the Prime Collective Communications Library (PCCL), a novel fault-tolerant collective communication library designed for distributed ML workloads over the public internet. PCCL introduces a new programming model that enables dynamic peer joining and failure recovery. The library implements efficient collective operations like all-reduce while providing robust fault tolerance mechanisms that allow the system to continue operating even when peers fail or join during ongoing operations. We demonstrate that PCCL's design enables practical solutions to dynamic membership challenges in workloads with repeated operations and deterministic state advancement. Our implementation passes extensive stress tests across all major operating systems, showing reliable operation even under rapid peer churn and concurrent collective operations. By dispatching to multiple connections, we can efficiently utilize cross-continental long-fat-pipe TCP WAN links, in our experiments achieving up to 45 Gbit/s of bandwidth utilization across Europe and 25 Gbit/s across North America and Europe. PCCL's architecture enables easy implementation of distributed low-communication optimization strategies like DiLoCo, which significantly reduce communication frequency. Combined with quantization, this leads to a significant reduction in the bandwidth required for distributed training workloads. PCCL also allows for concurrent collective operations, which enables optimization strategies like async DiLoCo, which can completely hide communication overhead by implementing one-step delayed parameter updates. PCCL can facilitate exact bit-parity of the shared state across peers in all cases induced by graceful or abrupt peer churn. While PCCL exposes a C99 API, Python bindings are available which are compatible with PyTorch alongside FSDP. PCCL is available under the open source MIT license.

SemiPFL: Personalized Semi-Supervised Federated Learning Framework for Edge Intelligence

Recent advances in wearable devices and Internet-of-Things (IoT) have led to massive growth in sensor data generated in edge devices. Labeling such massive data for classification tasks has proven to be challenging. In addition, data generated by different users bear various personal attributes and edge heterogeneity, rendering it impractical to develop a global model that adapts well to all users. Concerns over data privacy and communication costs also prohibit centralized data accumulation and training. We propose SemiPFL that supports edge users having no label or limited labeled datasets and a sizable amount of unlabeled data that is insufficient to train a well-performing model. In this work, edge users collaborate to train a Hyper-network in the server, generating personalized autoencoders for each user. After receiving updates from edge users, the server produces a set of base models for each user, which the users locally aggregate them using their own labeled dataset. We comprehensively evaluate our proposed framework on various public datasets from a wide range of application scenarios, from wearable health to IoT, and demonstrate that SemiPFL outperforms state-of-art federated learning frameworks under the same assumptions regarding user performance, network footprint, and computational consumption. We also show that the solution performs well for users without label or having limited labeled datasets and increasing performance for increased labeled data and number of users, signifying the effectiveness of SemiPFL for handling data heterogeneity and limited annotation. We also demonstrate the stability of SemiPFL for handling user hardware resource heterogeneity in three real-time scenarios.